The origin and understanding of the incretin concept

Jens F. Rehfeld

doi:10.3389/fendo.2018.00387

The origin and understanding of the incretin concept

Jens F. Rehfeld^*

^*Corresponding author af dette arbejde

Institut for Klinisk Medicin

21 Citationer (Scopus)

25 Downloads (Pure)

Abstract

Gastrointestinal hormones that stimulate insulin secretion at physiological concentrations are incretins. This concept has recently attracted considerable attention in the wake of drugs developed from the gut hormone GLP-1 (glucagon-like peptide-1) for diabetes therapy. But the renewed enthusiasm has also restricted the concept to just two hormones, GLP-1 and GIP (glucose-dependent insulinotropic polypeptide). The purpose of the present overview is two-fold: First to tell that the incretin concept is far from new. It has a more than a century long history full of ups and downs. Second, that the incretin concept may now have become too narrow. Thus, it is likely that incretin comprises additional gastrointestinal hormones, which interact with GIP and GLP-1 during normal meals containing protein, fat and complex carbohydrates (and not just pure glucose). Such broader incretin concept may stimulate development of novel gut hormone-derived drugs.

Originalsprog	Engelsk
Artikelnummer	387
Tidsskrift	Frontiers in Endocrinology
Vol/bind	9
Udgave nummer	JUL
Antal sider	7
ISSN	1664-2392
DOI	https://doi.org/10.3389/fendo.2018.00387
Status	Udgivet - 2018

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10.3389/fendo.2018.00387Licens: CC BY

The Origin and Understanding of the Incretin ConceptForlagets udgivne version, 597 KBLicens: CC BY

Citationsformater

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AB - Gastrointestinal hormones that stimulate insulin secretion at physiological concentrations are incretins. This concept has recently attracted considerable attention in the wake of drugs developed from the gut hormone GLP-1 (glucagon-like peptide-1) for diabetes therapy. But the renewed enthusiasm has also restricted the concept to just two hormones, GLP-1 and GIP (glucose-dependent insulinotropic polypeptide). The purpose of the present overview is two-fold: First to tell that the incretin concept is far from new. It has a more than a century long history full of ups and downs. Second, that the incretin concept may now have become too narrow. Thus, it is likely that incretin comprises additional gastrointestinal hormones, which interact with GIP and GLP-1 during normal meals containing protein, fat and complex carbohydrates (and not just pure glucose). Such broader incretin concept may stimulate development of novel gut hormone-derived drugs.

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The origin and understanding of the incretin concept

Abstract

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