The nude mouse as an in vivo model for human breast cancer invasion and metastasis

TY - JOUR

T1 - The nude mouse as an in vivo model for human breast cancer invasion and metastasis

AU - Brünner, N

AU - Boysen, B

AU - Rømer, J

AU - Spang-Thomsen, M

N1 - Keywords: Animals; Breast Neoplasms; Disease Models, Animal; Female; Genetic Markers; Humans; Mice; Mice, Nude; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Transplantation; Species Specificity; Transplantation, Heterologous; Tumor Cells, Cultured

PY - 1993

Y1 - 1993

N2 - Human breast cancer xenografts only rarely invade and metastasize in nude mice, and have therefore only had limited use as a model for studying mechanisms involved in breast cancer spreading. However, recent reports describe differences not only between various cell lines but also between strains of immune-deficient mice in terms of providing a model for studies of the invasive and metastatic capability of human breast cancer xenografts. Genetic labelling of human cancer cells with the lacZ gene is described as a specific and highly sensitive method for identification of micrometastases in such a model.

AB - Human breast cancer xenografts only rarely invade and metastasize in nude mice, and have therefore only had limited use as a model for studying mechanisms involved in breast cancer spreading. However, recent reports describe differences not only between various cell lines but also between strains of immune-deficient mice in terms of providing a model for studies of the invasive and metastatic capability of human breast cancer xenografts. Genetic labelling of human cancer cells with the lacZ gene is described as a specific and highly sensitive method for identification of micrometastases in such a model.

M3 - Journal article

C2 - 8435480

SN - 0167-6806

VL - 24

SP - 257

EP - 264

JO - Breast Cancer Research and Treatment

JF - Breast Cancer Research and Treatment

IS - 3

ER -