@article{75c91360654e11de8bc9000ea68e967b,
title = "The nude mouse as an in vivo model for human breast cancer invasion and metastasis",
abstract = "Human breast cancer xenografts only rarely invade and metastasize in nude mice, and have therefore only had limited use as a model for studying mechanisms involved in breast cancer spreading. However, recent reports describe differences not only between various cell lines but also between strains of immune-deficient mice in terms of providing a model for studies of the invasive and metastatic capability of human breast cancer xenografts. Genetic labelling of human cancer cells with the lacZ gene is described as a specific and highly sensitive method for identification of micrometastases in such a model.",
author = "N Br{\"u}nner and B Boysen and J R{\o}mer and M Spang-Thomsen",
note = "Keywords: Animals; Breast Neoplasms; Disease Models, Animal; Female; Genetic Markers; Humans; Mice; Mice, Nude; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Transplantation; Species Specificity; Transplantation, Heterologous; Tumor Cells, Cultured",
year = "1993",
language = "English",
volume = "24",
pages = "257--64",
journal = "Breast Cancer Research and Treatment",
issn = "0167-6806",
publisher = "Springer",
number = "3",
}
