The liquid-ordered state comes of age

Ole G. Mouritsen*

*Corresponding author for this work
    80 Citations (Scopus)

    Abstract

    Biomembranes are unique states of soft matter that share some of their materials properties with the mesophases of liquid crystals. Although of genuinely fluid character, membranes can display ordered states under physiological conditions, and it appears that their lateral organization and the related functional properties are intimately coupled to states in-between order and disorder. Hence, the liquid-ordered state of membranes, which owes its existence to the unique ability of cholesterol to mediate between order and disorder, has moved center stage in the characterization of membranes in terms of domains or rafts.

    Original languageEnglish
    JournalBiochimica et Biophysica Acta - Biomembranes
    Volume1798
    Issue number7
    Pages (from-to)1286-1288
    Number of pages3
    ISSN0005-2736
    DOIs
    Publication statusPublished - 1 Jul 2010

    Keywords

    • Cholesterol
    • Lipid bilayer
    • Lipid domains
    • Liquid-ordered phase

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