The lactococcal phages Tuc2009 and TP901-1 incorporate two alternate forms of their tail fiber into their virions for infection specialization

Stephen R. Stockdale; Jennifer  Mahony; Pascal Courtin; Marie-Pierre Chapot-Chartier; Jan-Peter van Pijkeren; Robert A. Britton; Horst Neve; Knut J. Heller; Basheer Yousef Aideh; Finn Kvist Vogensen; Douwe van Sinderen

doi:10.1074/jbc.M112.444901

The lactococcal phages Tuc2009 and TP901-1 incorporate two alternate forms of their tail fiber into their virions for infection specialization

Stephen R. Stockdale, Jennifer Mahony, Pascal Courtin, Marie-Pierre Chapot-Chartier, Jan-Peter van Pijkeren, Robert A. Britton, Horst Neve, Knut J. Heller, Basheer Yousef Aideh, Finn Kvist Vogensen, Douwe van Sinderen

Food Microbiology, Gut Health, and Fermentation

66 Citations (Scopus)

Abstract

Background: Siphoviridae virions often possess lytic domains facilitating host-penetration. Results: Tuc2009 and TP901-1 virions may contain full-length or truncated tail fibers, possessing or lacking a lytic domain, respectively. Conclusion: Phages with a lytic domain infect stationary phase cells better, whereas truncated derivatives have higher adsorption efficiencies. Significance: The heterogeneous phage population serves to most effectively infect bacteria where levels of cell wall crosslinkage differ.

Original language	English
Journal	Journal of Biological Chemistry
Volume	288
Issue number	8
Pages (from-to)	5581-5590
Number of pages	10
ISSN	0021-9258
DOIs	https://doi.org/10.1074/jbc.M112.444901
Publication status	Published - 22 Feb 2013

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Stockdale, S. R., Mahony, J., Courtin, P., Chapot-Chartier, M.-P., Pijkeren, J.-P. V., Britton, R. A., Neve, H., Heller, K. J., Aideh, B. Y., Vogensen, F. K., & Sinderen, D. V. (2013). The lactococcal phages Tuc2009 and TP901-1 incorporate two alternate forms of their tail fiber into their virions for infection specialization. Journal of Biological Chemistry, 288(8), 5581-5590. https://doi.org/10.1074/jbc.M112.444901

The lactococcal phages Tuc2009 and TP901-1 incorporate two alternate forms of their tail fiber into their virions for infection specialization. / Stockdale, Stephen R.; Mahony, Jennifer ; Courtin, Pascal et al.
In: Journal of Biological Chemistry, Vol. 288, No. 8, 22.02.2013, p. 5581-5590.

Research output: Contribution to journal › Journal article › Research › peer-review

Stockdale, SR, Mahony, J, Courtin, P, Chapot-Chartier, M-P, Pijkeren, J-PV, Britton, RA, Neve, H, Heller, KJ, Aideh, BY , Vogensen, FK & Sinderen, DV 2013, 'The lactococcal phages Tuc2009 and TP901-1 incorporate two alternate forms of their tail fiber into their virions for infection specialization', Journal of Biological Chemistry, vol. 288, no. 8, pp. 5581-5590. https://doi.org/10.1074/jbc.M112.444901

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title = "The lactococcal phages Tuc2009 and TP901-1 incorporate two alternate forms of their tail fiber into their virions for infection specialization",

abstract = "Background: Siphoviridae virions often possess lytic domains facilitating host-penetration. Results: Tuc2009 and TP901-1 virions may contain full-length or truncated tail fibers, possessing or lacking a lytic domain, respectively. Conclusion: Phages with a lytic domain infect stationary phase cells better, whereas truncated derivatives have higher adsorption efficiencies. Significance: The heterogeneous phage population serves to most effectively infect bacteria where levels of cell wall crosslinkage differ.",

author = "Stockdale, {Stephen R.} and Jennifer Mahony and Pascal Courtin and Marie-Pierre Chapot-Chartier and Pijkeren, {Jan-Peter van} and Britton, {Robert A.} and Horst Neve and Heller, {Knut J.} and Aideh, {Basheer Yousef} and Vogensen, {Finn Kvist} and Sinderen, {Douwe van}",

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AU - Courtin, Pascal

AU - Chapot-Chartier, Marie-Pierre

AU - Pijkeren, Jan-Peter van

AU - Britton, Robert A.

AU - Neve, Horst

AU - Heller, Knut J.

AU - Aideh, Basheer Yousef

AU - Vogensen, Finn Kvist

AU - Sinderen, Douwe van

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AB - Background: Siphoviridae virions often possess lytic domains facilitating host-penetration. Results: Tuc2009 and TP901-1 virions may contain full-length or truncated tail fibers, possessing or lacking a lytic domain, respectively. Conclusion: Phages with a lytic domain infect stationary phase cells better, whereas truncated derivatives have higher adsorption efficiencies. Significance: The heterogeneous phage population serves to most effectively infect bacteria where levels of cell wall crosslinkage differ.

U2 - 10.1074/jbc.M112.444901

DO - 10.1074/jbc.M112.444901

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ER -

The lactococcal phages Tuc2009 and TP901-1 incorporate two alternate forms of their tail fiber into their virions for infection specialization

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