The intraflagellar transport machinery in ciliary signaling

André Mourão; Søren Tvorup Christensen; Esben Lorentzen

doi:10.1016/j.sbi.2016.06.009

The intraflagellar transport machinery in ciliary signaling

André Mourão, Søren Tvorup Christensen^*, Esben Lorentzen

^*Corresponding author for this work

Cell Biology and Physiology

45 Citations (Scopus)

Abstract

Cilia and flagella on eukaryotic cells are slender microtubule-based projections surrounded by a membrane with a unique lipid and protein composition. It is now appreciated that cilia in addition to their established roles in motility also constitute hubs for cellular signaling by sensing external environmental cues necessary for organ development and maintenance of human health. Pathways reported to rely on the cilium organelle include Hedgehog, TGF-β, Wnt, PDGFRα, integrin and DNA damage repair signaling. An emerging theme in ciliary signaling is the requirement for active transport of signaling components into and out of the cilium proper. Here, we review the current state-of-the-art regarding the importance of intraflagellar transport and BBSome multi-subunit complexes in ciliary signaling.

Original language	English
Journal	Current Opinion in Structural Biology
Volume	41
Pages (from-to)	98-108
Number of pages	11
ISSN	0959-440X
DOIs	https://doi.org/10.1016/j.sbi.2016.06.009
Publication status	Published - 2016

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title = "The intraflagellar transport machinery in ciliary signaling",

abstract = "Cilia and flagella on eukaryotic cells are slender microtubule-based projections surrounded by a membrane with a unique lipid and protein composition. It is now appreciated that cilia in addition to their established roles in motility also constitute hubs for cellular signaling by sensing external environmental cues necessary for organ development and maintenance of human health. Pathways reported to rely on the cilium organelle include Hedgehog, TGF-β, Wnt, PDGFRα, integrin and DNA damage repair signaling. An emerging theme in ciliary signaling is the requirement for active transport of signaling components into and out of the cilium proper. Here, we review the current state-of-the-art regarding the importance of intraflagellar transport and BBSome multi-subunit complexes in ciliary signaling.",

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AU - Mourão, André

AU - Christensen, Søren Tvorup

AU - Lorentzen, Esben

PY - 2016

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N2 - Cilia and flagella on eukaryotic cells are slender microtubule-based projections surrounded by a membrane with a unique lipid and protein composition. It is now appreciated that cilia in addition to their established roles in motility also constitute hubs for cellular signaling by sensing external environmental cues necessary for organ development and maintenance of human health. Pathways reported to rely on the cilium organelle include Hedgehog, TGF-β, Wnt, PDGFRα, integrin and DNA damage repair signaling. An emerging theme in ciliary signaling is the requirement for active transport of signaling components into and out of the cilium proper. Here, we review the current state-of-the-art regarding the importance of intraflagellar transport and BBSome multi-subunit complexes in ciliary signaling.

AB - Cilia and flagella on eukaryotic cells are slender microtubule-based projections surrounded by a membrane with a unique lipid and protein composition. It is now appreciated that cilia in addition to their established roles in motility also constitute hubs for cellular signaling by sensing external environmental cues necessary for organ development and maintenance of human health. Pathways reported to rely on the cilium organelle include Hedgehog, TGF-β, Wnt, PDGFRα, integrin and DNA damage repair signaling. An emerging theme in ciliary signaling is the requirement for active transport of signaling components into and out of the cilium proper. Here, we review the current state-of-the-art regarding the importance of intraflagellar transport and BBSome multi-subunit complexes in ciliary signaling.

UR - https://doi.org/10.1016/j.sbi.2016.07.018

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DO - 10.1016/j.sbi.2016.06.009

M3 - Review

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AN - SCOPUS:84977489409

SN - 0959-440X

VL - 41

SP - 98

EP - 108

JO - Current Opinion in Structural Biology

JF - Current Opinion in Structural Biology

ER -

The intraflagellar transport machinery in ciliary signaling

Abstract

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