The intraflagellar transport machinery in ciliary signaling

TY - JOUR

T1 - The intraflagellar transport machinery in ciliary signaling

AU - Mourão, André

AU - Christensen, Søren Tvorup

AU - Lorentzen, Esben

PY - 2016

Y1 - 2016

N2 - Cilia and flagella on eukaryotic cells are slender microtubule-based projections surrounded by a membrane with a unique lipid and protein composition. It is now appreciated that cilia in addition to their established roles in motility also constitute hubs for cellular signaling by sensing external environmental cues necessary for organ development and maintenance of human health. Pathways reported to rely on the cilium organelle include Hedgehog, TGF-β, Wnt, PDGFRα, integrin and DNA damage repair signaling. An emerging theme in ciliary signaling is the requirement for active transport of signaling components into and out of the cilium proper. Here, we review the current state-of-the-art regarding the importance of intraflagellar transport and BBSome multi-subunit complexes in ciliary signaling.

AB - Cilia and flagella on eukaryotic cells are slender microtubule-based projections surrounded by a membrane with a unique lipid and protein composition. It is now appreciated that cilia in addition to their established roles in motility also constitute hubs for cellular signaling by sensing external environmental cues necessary for organ development and maintenance of human health. Pathways reported to rely on the cilium organelle include Hedgehog, TGF-β, Wnt, PDGFRα, integrin and DNA damage repair signaling. An emerging theme in ciliary signaling is the requirement for active transport of signaling components into and out of the cilium proper. Here, we review the current state-of-the-art regarding the importance of intraflagellar transport and BBSome multi-subunit complexes in ciliary signaling.

UR - https://doi.org/10.1016/j.sbi.2016.07.018

U2 - 10.1016/j.sbi.2016.06.009

DO - 10.1016/j.sbi.2016.06.009

M3 - Review

C2 - 27393972

AN - SCOPUS:84977489409

SN - 0959-440X

VL - 41

SP - 98

EP - 108

JO - Current Opinion in Structural Biology

JF - Current Opinion in Structural Biology

ER -