The impact of CCR5-Δ32 deletion on C-reactive protein levels and cardiovascular disease: Results from the Danish Blood Donor Study

Khoa Manh Dinh; Ole B Pedersen; Mikkel S Petersen; Erik Sørensen; Cecilie J Sørensen; Kathrine Agergård Kaspersen; Margit Hørup Larsen; Bjarne Kuno Møller; Henrik Hjalgrim; Henrik Ullum; Christian Erikstrup

doi:10.1016/j.atherosclerosis.2015.07.031

The impact of CCR5-Δ32 deletion on C-reactive protein levels and cardiovascular disease: Results from the Danish Blood Donor Study

Khoa Manh Dinh, Ole B Pedersen, Mikkel S Petersen, Erik Sørensen, Cecilie J Sørensen, Kathrine Agergård Kaspersen, Margit Hørup Larsen, Bjarne Kuno Møller, Henrik Hjalgrim, Henrik Ullum, Christian Erikstrup

Department of Clinical Medicine

4 Citations (Scopus)

Abstract

BACKGROUND AND PURPOSE: The C-C chemokine receptor 5-Δ32 deletion (CCR5-Δ32) has been associated with lower levels of C-reactive protein (CRP), but the effect on cardiovascular diseases is uncertain. This study addresses the impact of CCR5-Δ32 on the risk of low-grade inflammation and hospitalization with cardiovascular diseases in a large cohort of blood donors.

METHODS: Genotyping of 15,206 healthy participants from The Danish Blood Donor Study for CCR5-Δ32 was performed and combined with CRP measurements and questionnaire data. Cardiovascular disease diagnoses were identified by ICD-10 codes in the Danish National Patient Registry.

RESULTS: CCR5-Δ32-carriers had a higher risk of hospitalization for cardiovascular diseases when compared with wild-type homozygotes (hazard ratio = 1.35, 95%-confidence interval: 1.00-1.87). CRP levels were unaffected by the CCR5-Δ32 deletion.

CONCLUSION: In this cohort, carriers of the CCR5-Δ32 deletion had normal CRP levels but a borderline significant increased risk of cardiovascular diseases.

Original language	English
Journal	Atherosclerosis
Volume	242
Issue number	1
Pages (from-to)	222-5
Number of pages	4
ISSN	0021-9150
DOIs	https://doi.org/10.1016/j.atherosclerosis.2015.07.031
Publication status	Published - 1 Aug 2015

Keywords

Adult
Biomarkers
C-Reactive Protein
Cardiovascular Diseases
Denmark
Female
Gene Deletion
Genetic Markers
Genetic Predisposition to Disease
Heterozygote
Homozygote
Hospitalization
Humans
Inflammation
Male
Middle Aged
Phenotype
Receptors, CCR5
Risk Assessment
Risk Factors
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.atherosclerosis.2015.07.031

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Dinh, K. M., Pedersen, O. B., Petersen, M. S., Sørensen, E., Sørensen, C. J., Kaspersen, K. A., Larsen, M. H., Møller, B. K., Hjalgrim, H., Ullum, H., & Erikstrup, C. (2015). The impact of CCR5-Δ32 deletion on C-reactive protein levels and cardiovascular disease: Results from the Danish Blood Donor Study. Atherosclerosis, 242(1), 222-5. https://doi.org/10.1016/j.atherosclerosis.2015.07.031

Dinh, KM, Pedersen, OB, Petersen, MS, Sørensen, E, Sørensen, CJ, Kaspersen, KA, Larsen, MH, Møller, BK, Hjalgrim, H, Ullum, H & Erikstrup, C 2015, 'The impact of CCR5-Δ32 deletion on C-reactive protein levels and cardiovascular disease: Results from the Danish Blood Donor Study', Atherosclerosis, vol. 242, no. 1, pp. 222-5. https://doi.org/10.1016/j.atherosclerosis.2015.07.031

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title = "The impact of CCR5-Δ32 deletion on C-reactive protein levels and cardiovascular disease: Results from the Danish Blood Donor Study",

abstract = "BACKGROUND AND PURPOSE: The C-C chemokine receptor 5-Δ32 deletion (CCR5-Δ32) has been associated with lower levels of C-reactive protein (CRP), but the effect on cardiovascular diseases is uncertain. This study addresses the impact of CCR5-Δ32 on the risk of low-grade inflammation and hospitalization with cardiovascular diseases in a large cohort of blood donors.METHODS: Genotyping of 15,206 healthy participants from The Danish Blood Donor Study for CCR5-Δ32 was performed and combined with CRP measurements and questionnaire data. Cardiovascular disease diagnoses were identified by ICD-10 codes in the Danish National Patient Registry.RESULTS: CCR5-Δ32-carriers had a higher risk of hospitalization for cardiovascular diseases when compared with wild-type homozygotes (hazard ratio = 1.35, 95%-confidence interval: 1.00-1.87). CRP levels were unaffected by the CCR5-Δ32 deletion.CONCLUSION: In this cohort, carriers of the CCR5-Δ32 deletion had normal CRP levels but a borderline significant increased risk of cardiovascular diseases.",

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author = "Dinh, {Khoa Manh} and Pedersen, {Ole B} and Petersen, {Mikkel S} and Erik S{\o}rensen and S{\o}rensen, {Cecilie J} and Kaspersen, {Kathrine Agerg{\aa}rd} and Larsen, {Margit H{\o}rup} and M{\o}ller, {Bjarne Kuno} and Henrik Hjalgrim and Henrik Ullum and Christian Erikstrup",

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doi = "10.1016/j.atherosclerosis.2015.07.031",

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T1 - The impact of CCR5-Δ32 deletion on C-reactive protein levels and cardiovascular disease

T2 - Results from the Danish Blood Donor Study

AU - Dinh, Khoa Manh

AU - Pedersen, Ole B

AU - Petersen, Mikkel S

AU - Sørensen, Erik

AU - Sørensen, Cecilie J

AU - Kaspersen, Kathrine Agergård

AU - Larsen, Margit Hørup

AU - Møller, Bjarne Kuno

AU - Hjalgrim, Henrik

AU - Ullum, Henrik

AU - Erikstrup, Christian

PY - 2015/8/1

Y1 - 2015/8/1

N2 - BACKGROUND AND PURPOSE: The C-C chemokine receptor 5-Δ32 deletion (CCR5-Δ32) has been associated with lower levels of C-reactive protein (CRP), but the effect on cardiovascular diseases is uncertain. This study addresses the impact of CCR5-Δ32 on the risk of low-grade inflammation and hospitalization with cardiovascular diseases in a large cohort of blood donors.METHODS: Genotyping of 15,206 healthy participants from The Danish Blood Donor Study for CCR5-Δ32 was performed and combined with CRP measurements and questionnaire data. Cardiovascular disease diagnoses were identified by ICD-10 codes in the Danish National Patient Registry.RESULTS: CCR5-Δ32-carriers had a higher risk of hospitalization for cardiovascular diseases when compared with wild-type homozygotes (hazard ratio = 1.35, 95%-confidence interval: 1.00-1.87). CRP levels were unaffected by the CCR5-Δ32 deletion.CONCLUSION: In this cohort, carriers of the CCR5-Δ32 deletion had normal CRP levels but a borderline significant increased risk of cardiovascular diseases.

AB - BACKGROUND AND PURPOSE: The C-C chemokine receptor 5-Δ32 deletion (CCR5-Δ32) has been associated with lower levels of C-reactive protein (CRP), but the effect on cardiovascular diseases is uncertain. This study addresses the impact of CCR5-Δ32 on the risk of low-grade inflammation and hospitalization with cardiovascular diseases in a large cohort of blood donors.METHODS: Genotyping of 15,206 healthy participants from The Danish Blood Donor Study for CCR5-Δ32 was performed and combined with CRP measurements and questionnaire data. Cardiovascular disease diagnoses were identified by ICD-10 codes in the Danish National Patient Registry.RESULTS: CCR5-Δ32-carriers had a higher risk of hospitalization for cardiovascular diseases when compared with wild-type homozygotes (hazard ratio = 1.35, 95%-confidence interval: 1.00-1.87). CRP levels were unaffected by the CCR5-Δ32 deletion.CONCLUSION: In this cohort, carriers of the CCR5-Δ32 deletion had normal CRP levels but a borderline significant increased risk of cardiovascular diseases.

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KW - Homozygote

KW - Hospitalization

KW - Humans

KW - Inflammation

KW - Male

KW - Middle Aged

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KW - Receptors, CCR5

KW - Risk Assessment

KW - Risk Factors

KW - Comparative Study

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DO - 10.1016/j.atherosclerosis.2015.07.031

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SN - 0021-9150

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SP - 222

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JO - Atherosclerosis

JF - Atherosclerosis

IS - 1

ER -

The impact of CCR5-Δ32 deletion on C-reactive protein levels and cardiovascular disease: Results from the Danish Blood Donor Study

Abstract

Keywords

UN SDGs

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