The impact of CCR5-Δ32 deletion on C-reactive protein levels and cardiovascular disease: Results from the Danish Blood Donor Study

Khoa Manh Dinh; Ole B Pedersen; Mikkel S Petersen; Erik Sørensen; Cecilie J Sørensen; Kathrine Agergård Kaspersen; Margit Hørup Larsen; Bjarne Kuno Møller; Henrik Hjalgrim; Henrik Ullum; Christian Erikstrup

doi:10.1016/j.atherosclerosis.2015.07.031

The impact of CCR5-Δ32 deletion on C-reactive protein levels and cardiovascular disease: Results from the Danish Blood Donor Study

Khoa Manh Dinh, Ole B Pedersen, Mikkel S Petersen, Erik Sørensen, Cecilie J Sørensen, Kathrine Agergård Kaspersen, Margit Hørup Larsen, Bjarne Kuno Møller, Henrik Hjalgrim, Henrik Ullum, Christian Erikstrup

Institut for Klinisk Medicin

4 Citationer (Scopus)

Abstract

BACKGROUND AND PURPOSE: The C-C chemokine receptor 5-Δ32 deletion (CCR5-Δ32) has been associated with lower levels of C-reactive protein (CRP), but the effect on cardiovascular diseases is uncertain. This study addresses the impact of CCR5-Δ32 on the risk of low-grade inflammation and hospitalization with cardiovascular diseases in a large cohort of blood donors.

METHODS: Genotyping of 15,206 healthy participants from The Danish Blood Donor Study for CCR5-Δ32 was performed and combined with CRP measurements and questionnaire data. Cardiovascular disease diagnoses were identified by ICD-10 codes in the Danish National Patient Registry.

RESULTS: CCR5-Δ32-carriers had a higher risk of hospitalization for cardiovascular diseases when compared with wild-type homozygotes (hazard ratio = 1.35, 95%-confidence interval: 1.00-1.87). CRP levels were unaffected by the CCR5-Δ32 deletion.

CONCLUSION: In this cohort, carriers of the CCR5-Δ32 deletion had normal CRP levels but a borderline significant increased risk of cardiovascular diseases.

Originalsprog	Engelsk
Tidsskrift	Atherosclerosis
Vol/bind	242
Udgave nummer	1
Sider (fra-til)	222-5
Antal sider	4
ISSN	0021-9150
DOI	https://doi.org/10.1016/j.atherosclerosis.2015.07.031
Status	Udgivet - 1 aug. 2015

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Dinh, K. M., Pedersen, O. B., Petersen, M. S., Sørensen, E., Sørensen, C. J., Kaspersen, K. A., Larsen, M. H., Møller, B. K., Hjalgrim, H., Ullum, H., & Erikstrup, C. (2015). The impact of CCR5-Δ32 deletion on C-reactive protein levels and cardiovascular disease: Results from the Danish Blood Donor Study. Atherosclerosis, 242(1), 222-5. https://doi.org/10.1016/j.atherosclerosis.2015.07.031

Dinh, KM, Pedersen, OB, Petersen, MS, Sørensen, E, Sørensen, CJ, Kaspersen, KA, Larsen, MH, Møller, BK, Hjalgrim, H, Ullum, H & Erikstrup, C 2015, 'The impact of CCR5-Δ32 deletion on C-reactive protein levels and cardiovascular disease: Results from the Danish Blood Donor Study', Atherosclerosis, bind 242, nr. 1, s. 222-5. https://doi.org/10.1016/j.atherosclerosis.2015.07.031

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title = "The impact of CCR5-Δ32 deletion on C-reactive protein levels and cardiovascular disease: Results from the Danish Blood Donor Study",

abstract = "BACKGROUND AND PURPOSE: The C-C chemokine receptor 5-Δ32 deletion (CCR5-Δ32) has been associated with lower levels of C-reactive protein (CRP), but the effect on cardiovascular diseases is uncertain. This study addresses the impact of CCR5-Δ32 on the risk of low-grade inflammation and hospitalization with cardiovascular diseases in a large cohort of blood donors.METHODS: Genotyping of 15,206 healthy participants from The Danish Blood Donor Study for CCR5-Δ32 was performed and combined with CRP measurements and questionnaire data. Cardiovascular disease diagnoses were identified by ICD-10 codes in the Danish National Patient Registry.RESULTS: CCR5-Δ32-carriers had a higher risk of hospitalization for cardiovascular diseases when compared with wild-type homozygotes (hazard ratio = 1.35, 95%-confidence interval: 1.00-1.87). CRP levels were unaffected by the CCR5-Δ32 deletion.CONCLUSION: In this cohort, carriers of the CCR5-Δ32 deletion had normal CRP levels but a borderline significant increased risk of cardiovascular diseases.",

keywords = "Adult, Biomarkers, C-Reactive Protein, Cardiovascular Diseases, Denmark, Female, Gene Deletion, Genetic Markers, Genetic Predisposition to Disease, Heterozygote, Homozygote, Hospitalization, Humans, Inflammation, Male, Middle Aged, Phenotype, Receptors, CCR5, Risk Assessment, Risk Factors, Comparative Study, Journal Article, Research Support, Non-U.S. Gov't",

author = "Dinh, {Khoa Manh} and Pedersen, {Ole B} and Petersen, {Mikkel S} and Erik S{\o}rensen and S{\o}rensen, {Cecilie J} and Kaspersen, {Kathrine Agerg{\aa}rd} and Larsen, {Margit H{\o}rup} and M{\o}ller, {Bjarne Kuno} and Henrik Hjalgrim and Henrik Ullum and Christian Erikstrup",

year = "2015",

month = aug,

day = "1",

doi = "10.1016/j.atherosclerosis.2015.07.031",

language = "English",

volume = "242",

pages = "222--5",

journal = "Atherosclerosis",

issn = "0021-9150",

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number = "1",

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T1 - The impact of CCR5-Δ32 deletion on C-reactive protein levels and cardiovascular disease

T2 - Results from the Danish Blood Donor Study

AU - Dinh, Khoa Manh

AU - Pedersen, Ole B

AU - Petersen, Mikkel S

AU - Sørensen, Erik

AU - Sørensen, Cecilie J

AU - Kaspersen, Kathrine Agergård

AU - Larsen, Margit Hørup

AU - Møller, Bjarne Kuno

AU - Hjalgrim, Henrik

AU - Ullum, Henrik

AU - Erikstrup, Christian

PY - 2015/8/1

Y1 - 2015/8/1

N2 - BACKGROUND AND PURPOSE: The C-C chemokine receptor 5-Δ32 deletion (CCR5-Δ32) has been associated with lower levels of C-reactive protein (CRP), but the effect on cardiovascular diseases is uncertain. This study addresses the impact of CCR5-Δ32 on the risk of low-grade inflammation and hospitalization with cardiovascular diseases in a large cohort of blood donors.METHODS: Genotyping of 15,206 healthy participants from The Danish Blood Donor Study for CCR5-Δ32 was performed and combined with CRP measurements and questionnaire data. Cardiovascular disease diagnoses were identified by ICD-10 codes in the Danish National Patient Registry.RESULTS: CCR5-Δ32-carriers had a higher risk of hospitalization for cardiovascular diseases when compared with wild-type homozygotes (hazard ratio = 1.35, 95%-confidence interval: 1.00-1.87). CRP levels were unaffected by the CCR5-Δ32 deletion.CONCLUSION: In this cohort, carriers of the CCR5-Δ32 deletion had normal CRP levels but a borderline significant increased risk of cardiovascular diseases.

AB - BACKGROUND AND PURPOSE: The C-C chemokine receptor 5-Δ32 deletion (CCR5-Δ32) has been associated with lower levels of C-reactive protein (CRP), but the effect on cardiovascular diseases is uncertain. This study addresses the impact of CCR5-Δ32 on the risk of low-grade inflammation and hospitalization with cardiovascular diseases in a large cohort of blood donors.METHODS: Genotyping of 15,206 healthy participants from The Danish Blood Donor Study for CCR5-Δ32 was performed and combined with CRP measurements and questionnaire data. Cardiovascular disease diagnoses were identified by ICD-10 codes in the Danish National Patient Registry.RESULTS: CCR5-Δ32-carriers had a higher risk of hospitalization for cardiovascular diseases when compared with wild-type homozygotes (hazard ratio = 1.35, 95%-confidence interval: 1.00-1.87). CRP levels were unaffected by the CCR5-Δ32 deletion.CONCLUSION: In this cohort, carriers of the CCR5-Δ32 deletion had normal CRP levels but a borderline significant increased risk of cardiovascular diseases.

KW - Adult

KW - Biomarkers

KW - C-Reactive Protein

KW - Cardiovascular Diseases

KW - Denmark

KW - Female

KW - Gene Deletion

KW - Genetic Markers

KW - Genetic Predisposition to Disease

KW - Heterozygote

KW - Homozygote

KW - Hospitalization

KW - Humans

KW - Inflammation

KW - Male

KW - Middle Aged

KW - Phenotype

KW - Receptors, CCR5

KW - Risk Assessment

KW - Risk Factors

KW - Comparative Study

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1016/j.atherosclerosis.2015.07.031

DO - 10.1016/j.atherosclerosis.2015.07.031

M3 - Journal article

C2 - 26222902

SN - 0021-9150

VL - 242

SP - 222

EP - 225

JO - Atherosclerosis

JF - Atherosclerosis

IS - 1

ER -

The impact of CCR5-Δ32 deletion on C-reactive protein levels and cardiovascular disease: Results from the Danish Blood Donor Study

Abstract

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