The hippocampus in multiple sclerosis

Maria A Rocca; Frederik Barkhof; John De Luca; Jonas Frisén; Jeroen J G Geurts; Hanneke E Hulst; Jaume Sastre-Garriga; Massimo Filippi; MAGNIMS study group; Frederik Barkhof; Olga Ciccarelli; Nicola De Stefano; Christian Enzinger; Massimo Filippi; Jette Lautrup Fredriksen; Claudio Gasperini; Ludwig Kappos; Jacqueline Palace; Maria A Rocca; Alex Rovira; Jaume Sastre-Garriga; Hugo Vrenken; Tarek A Yousry

doi:10.1016/S1474-4422(18)30309-0

The hippocampus in multiple sclerosis

Maria A Rocca, Frederik Barkhof, John De Luca, Jonas Frisén, Jeroen J G Geurts, Hanneke E Hulst, Jaume Sastre-Garriga, Massimo Filippi, MAGNIMS study group, Frederik Barkhof, Olga Ciccarelli, Nicola De Stefano, Christian Enzinger, Massimo Filippi, Jette Lautrup Fredriksen, Claudio Gasperini, Ludwig Kappos, Jacqueline Palace, Maria A Rocca, Alex RoviraJaume Sastre-Garriga, Hugo Vrenken, Tarek A Yousry

Department of Clinical Medicine

30 Citations (Scopus)

Abstract

Some of the clinical manifestations of multiple sclerosis, such as memory impairment and depression, are, at least partly, related to involvement of the hippocampus. Pathological studies have shown extensive demyelination, neuronal damage, and synaptic abnormalities in the hippocampus of patients with multiple sclerosis, and improvements in MRI technology have provided novel ways to assess hippocampal involvement in vivo. It is now accepted that clinical manifestations related to the hippocampus are due not only to focal hippocampal damage, but also to disconnection of the hippocampus from several brain networks. Evidence suggests anatomical and functional subspecialisation of the different hippocampal subfields, resulting in variability between regions in the extent to which damage and repair occur. The hippocampus also has important roles in plasticity and neurogenesis, both of which potentially contribute to functional preservation and restoration. These findings underline the importance of evaluation of the hippocampus not only to improve understanding of the clinical manifestations of multiple sclerosis, but also as a potential future target for treatment.

Original language	English
Journal	Lancet Neurology
Volume	17
Issue number	10
Pages (from-to)	918-926
ISSN	1474-4422
DOIs	https://doi.org/10.1016/S1474-4422(18)30309-0
Publication status	Published - 1 Oct 2018

Keywords

Cognitive Dysfunction/diagnostic imaging
Hippocampus/diagnostic imaging
Humans
Multiple Sclerosis/complications

Access to Document

10.1016/S1474-4422(18)30309-0

Cite this

Rocca, M. A., Barkhof, F., De Luca, J., Frisén, J., Geurts, J. J. G., Hulst, H. E., Sastre-Garriga, J., Filippi, M., MAGNIMS study group, Barkhof, F., Ciccarelli, O., De Stefano, N., Enzinger, C., Filippi, M., Fredriksen, J. L., Gasperini, C., Kappos, L., Palace, J., Rocca, M. A., ... Yousry, T. A. (2018). The hippocampus in multiple sclerosis. Lancet Neurology, 17(10), 918-926. https://doi.org/10.1016/S1474-4422(18)30309-0

Rocca, MA, Barkhof, F, De Luca, J, Frisén, J, Geurts, JJG, Hulst, HE, Sastre-Garriga, J, Filippi, M, MAGNIMS study group, Barkhof, F, Ciccarelli, O, De Stefano, N, Enzinger, C, Filippi, M, Fredriksen, JL, Gasperini, C, Kappos, L, Palace, J, Rocca, MA, Rovira, A, Sastre-Garriga, J, Vrenken, H & Yousry, TA 2018, 'The hippocampus in multiple sclerosis', Lancet Neurology, vol. 17, no. 10, pp. 918-926. https://doi.org/10.1016/S1474-4422(18)30309-0

@article{d3b0cec68c92468fa019fac402d94a8a,

title = "The hippocampus in multiple sclerosis",

abstract = "Some of the clinical manifestations of multiple sclerosis, such as memory impairment and depression, are, at least partly, related to involvement of the hippocampus. Pathological studies have shown extensive demyelination, neuronal damage, and synaptic abnormalities in the hippocampus of patients with multiple sclerosis, and improvements in MRI technology have provided novel ways to assess hippocampal involvement in vivo. It is now accepted that clinical manifestations related to the hippocampus are due not only to focal hippocampal damage, but also to disconnection of the hippocampus from several brain networks. Evidence suggests anatomical and functional subspecialisation of the different hippocampal subfields, resulting in variability between regions in the extent to which damage and repair occur. The hippocampus also has important roles in plasticity and neurogenesis, both of which potentially contribute to functional preservation and restoration. These findings underline the importance of evaluation of the hippocampus not only to improve understanding of the clinical manifestations of multiple sclerosis, but also as a potential future target for treatment.",

keywords = "Cognitive Dysfunction/diagnostic imaging, Hippocampus/diagnostic imaging, Humans, Multiple Sclerosis/complications",

author = "Rocca, {Maria A} and Frederik Barkhof and {De Luca}, John and Jonas Fris{\'e}n and Geurts, {Jeroen J G} and Hulst, {Hanneke E} and Jaume Sastre-Garriga and Massimo Filippi and {MAGNIMS study group} and Frederik Barkhof and Olga Ciccarelli and {De Stefano}, Nicola and Christian Enzinger and Massimo Filippi and Fredriksen, {Jette Lautrup} and Claudio Gasperini and Ludwig Kappos and Jacqueline Palace and Rocca, {Maria A} and Alex Rovira and Jaume Sastre-Garriga and Hugo Vrenken and Yousry, {Tarek A}",

year = "2018",

month = oct,

day = "1",

doi = "10.1016/S1474-4422(18)30309-0",

language = "English",

volume = "17",

pages = "918--926",

journal = "The Lancet Neurology",

issn = "1474-4422",

publisher = "TheLancet Publishing Group",

number = "10",

}

TY - JOUR

T1 - The hippocampus in multiple sclerosis

AU - Rocca, Maria A

AU - Barkhof, Frederik

AU - De Luca, John

AU - Frisén, Jonas

AU - Geurts, Jeroen J G

AU - Hulst, Hanneke E

AU - Sastre-Garriga, Jaume

AU - Filippi, Massimo

AU - MAGNIMS study group

AU - Barkhof, Frederik

AU - Ciccarelli, Olga

AU - De Stefano, Nicola

AU - Enzinger, Christian

AU - Filippi, Massimo

AU - Fredriksen, Jette Lautrup

AU - Gasperini, Claudio

AU - Kappos, Ludwig

AU - Palace, Jacqueline

AU - Rocca, Maria A

AU - Rovira, Alex

AU - Sastre-Garriga, Jaume

AU - Vrenken, Hugo

AU - Yousry, Tarek A

PY - 2018/10/1

Y1 - 2018/10/1

N2 - Some of the clinical manifestations of multiple sclerosis, such as memory impairment and depression, are, at least partly, related to involvement of the hippocampus. Pathological studies have shown extensive demyelination, neuronal damage, and synaptic abnormalities in the hippocampus of patients with multiple sclerosis, and improvements in MRI technology have provided novel ways to assess hippocampal involvement in vivo. It is now accepted that clinical manifestations related to the hippocampus are due not only to focal hippocampal damage, but also to disconnection of the hippocampus from several brain networks. Evidence suggests anatomical and functional subspecialisation of the different hippocampal subfields, resulting in variability between regions in the extent to which damage and repair occur. The hippocampus also has important roles in plasticity and neurogenesis, both of which potentially contribute to functional preservation and restoration. These findings underline the importance of evaluation of the hippocampus not only to improve understanding of the clinical manifestations of multiple sclerosis, but also as a potential future target for treatment.

AB - Some of the clinical manifestations of multiple sclerosis, such as memory impairment and depression, are, at least partly, related to involvement of the hippocampus. Pathological studies have shown extensive demyelination, neuronal damage, and synaptic abnormalities in the hippocampus of patients with multiple sclerosis, and improvements in MRI technology have provided novel ways to assess hippocampal involvement in vivo. It is now accepted that clinical manifestations related to the hippocampus are due not only to focal hippocampal damage, but also to disconnection of the hippocampus from several brain networks. Evidence suggests anatomical and functional subspecialisation of the different hippocampal subfields, resulting in variability between regions in the extent to which damage and repair occur. The hippocampus also has important roles in plasticity and neurogenesis, both of which potentially contribute to functional preservation and restoration. These findings underline the importance of evaluation of the hippocampus not only to improve understanding of the clinical manifestations of multiple sclerosis, but also as a potential future target for treatment.

KW - Cognitive Dysfunction/diagnostic imaging

KW - Hippocampus/diagnostic imaging

KW - Humans

KW - Multiple Sclerosis/complications

U2 - 10.1016/S1474-4422(18)30309-0

DO - 10.1016/S1474-4422(18)30309-0

M3 - Comment/debate

C2 - 30264730

SN - 1474-4422

VL - 17

SP - 918

EP - 926

JO - The Lancet Neurology

JF - The Lancet Neurology

IS - 10

ER -

The hippocampus in multiple sclerosis

Abstract

Keywords

Access to Document

Fingerprint

Cite this