The gut microbiota in type 2 diabetes

Trine Nielsen; Kristine Højgaard Allin; Oluf Pedersen

doi:10.1007/978-3-319-01574-3_13

The gut microbiota in type 2 diabetes

Trine Nielsen, Kristine Højgaard Allin, Oluf Pedersen^*

^*Corresponding author for this work

Abstract

The exploration of the gut microbiota has intensified within the past decade with the introduction of cultivation-independent methods. By investigation of the gut bacterial genes, our understanding of the compositional and functional capability of the gut microbiome has increased. It is now widely recognized that the gut microbiota has profound effect on host metabolism and recently changes in the gut microbiota have been associated with type 2 diabetes. Animal models and human studies have linked changes in the gut microbiota to the induction of low-grade inflammation, altered immune response, and changes in lipid and glucose metabolism. Several factors have been identified that might affect the healthy microbiota, potentially inducing a dysbiotic microbiota associated with a disease state. This increased understanding of the gut microbiota might potentially contribute to targeted intervention strategies to prevent or treat type 2 diabetes.

Original language	English
Title of host publication	The Genetics of Type 2 Diabetes and Related Traits: Biology, Physiology and Translation
Number of pages	19
Publisher	Springer
Publication date	1 Jan 2016
Pages	275-293
Chapter	13
ISBN (Print)	9783319015736
ISBN (Electronic)	9783319015743
DOIs	https://doi.org/10.1007/978-3-319-01574-3_13
Publication status	Published - 1 Jan 2016

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AB - The exploration of the gut microbiota has intensified within the past decade with the introduction of cultivation-independent methods. By investigation of the gut bacterial genes, our understanding of the compositional and functional capability of the gut microbiome has increased. It is now widely recognized that the gut microbiota has profound effect on host metabolism and recently changes in the gut microbiota have been associated with type 2 diabetes. Animal models and human studies have linked changes in the gut microbiota to the induction of low-grade inflammation, altered immune response, and changes in lipid and glucose metabolism. Several factors have been identified that might affect the healthy microbiota, potentially inducing a dysbiotic microbiota associated with a disease state. This increased understanding of the gut microbiota might potentially contribute to targeted intervention strategies to prevent or treat type 2 diabetes.

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The gut microbiota in type 2 diabetes

Abstract

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