The gut microbiota in type 2 diabetes

TY - CHAP

T1 - The gut microbiota in type 2 diabetes

AU - Nielsen, Trine

AU - Allin, Kristine Højgaard

AU - Pedersen, Oluf

PY - 2016/1/1

Y1 - 2016/1/1

N2 - The exploration of the gut microbiota has intensified within the past decade with the introduction of cultivation-independent methods. By investigation of the gut bacterial genes, our understanding of the compositional and functional capability of the gut microbiome has increased. It is now widely recognized that the gut microbiota has profound effect on host metabolism and recently changes in the gut microbiota have been associated with type 2 diabetes. Animal models and human studies have linked changes in the gut microbiota to the induction of low-grade inflammation, altered immune response, and changes in lipid and glucose metabolism. Several factors have been identified that might affect the healthy microbiota, potentially inducing a dysbiotic microbiota associated with a disease state. This increased understanding of the gut microbiota might potentially contribute to targeted intervention strategies to prevent or treat type 2 diabetes.

AB - The exploration of the gut microbiota has intensified within the past decade with the introduction of cultivation-independent methods. By investigation of the gut bacterial genes, our understanding of the compositional and functional capability of the gut microbiome has increased. It is now widely recognized that the gut microbiota has profound effect on host metabolism and recently changes in the gut microbiota have been associated with type 2 diabetes. Animal models and human studies have linked changes in the gut microbiota to the induction of low-grade inflammation, altered immune response, and changes in lipid and glucose metabolism. Several factors have been identified that might affect the healthy microbiota, potentially inducing a dysbiotic microbiota associated with a disease state. This increased understanding of the gut microbiota might potentially contribute to targeted intervention strategies to prevent or treat type 2 diabetes.

UR - http://www.scopus.com/inward/record.url?scp=84978274888&partnerID=8YFLogxK

U2 - 10.1007/978-3-319-01574-3_13

DO - 10.1007/978-3-319-01574-3_13

M3 - Book chapter

AN - SCOPUS:84978274888

SN - 9783319015736

SP - 275

EP - 293

BT - The Genetics of Type 2 Diabetes and Related Traits: Biology, Physiology and Translation

PB - Springer

ER -