Abstract
Previous studies suggested that gastrin-releasing peptide (a neuropeptide found in rat oxyntic mucosa) and oxyntomodulin (a glucagon-containing peptide of mammalian gut) could directly affect the acid secretion of the parietal cells. We therefore studied their effect on gastric acid production in vitro by measuring [14C]-aminopyrine accumulation, a reliable index of H+ generation, in isolated rat parietal cells. However, neither gastrin-releasing peptide nor oxyntomodulin influenced basal acid secretion or histamine-stimulated gastric acid secretion. Electron-microscopic studies of unstimulated and histamine-stimulated parietal cells confirmed that the cells retained the normal morphology of intracellular organelles and that the cells responded to physiological stimulation by marked expansion of the intracellular canaliculi.
| Original language | English |
|---|---|
| Journal | Digestion |
| Volume | 40 |
| Issue number | 3 |
| Pages (from-to) | 144-51 |
| Number of pages | 8 |
| ISSN | 0012-2823 |
| Publication status | Published - 1988 |
Keywords
- Aminopyrine
- Animals
- Gastric Acid
- Gastrin-Releasing Peptide
- Gastrins
- Gastrointestinal Hormones
- Glicentin
- Glucagon
- Glucagon-Like Peptides
- Histamine
- Microscopy, Electron
- Oxyntomodulin
- Parietal Cells, Gastric
- Peptide Fragments
- Peptides
- Protein Precursors
- Rats