Abstract
In this chapter we discuss the possibility for proteins to self-assemble in large-scale amyloid aggregates of spherical shape termed amyloid spherulites. Under specific experimental conditions, amyloid spherulites are recognized as a significant component occurring in several protein model systems used for in vitro fibrillation studies. The state of the art is discussed together with some of the recent experimental results addressing the effect of specific factors on the growth of spherulites in solutions of bovine insulin. Moreover, future perspectives and ideas for a deeper characterization of this amyloid structure are also reported.
| Original language | English |
|---|---|
| Title of host publication | Bio-nanoimaging : Protein Misfolding and Aggregation |
| Editors | Vladimir Uversky, Yuri Lyubchenko |
| Publisher | Academic Press |
| Publication date | Nov 2013 |
| Pages | 301-308 |
| Chapter | 28 |
| ISBN (Electronic) | 978-0-12-394431-3 |
| DOIs | |
| Publication status | Published - Nov 2013 |
| Externally published | Yes |