The Formation of Amyloid-like Superstructures: On the Growth of Amyloid Spherulites

TY - CHAP

T1 - The Formation of Amyloid-like Superstructures: On the Growth of Amyloid Spherulites

AU - Foderà, Vito

AU - Donald, AM

PY - 2013/11

Y1 - 2013/11

N2 - In this chapter we discuss the possibility for proteins to self-assemble in large-scale amyloid aggregates of spherical shape termed amyloid spherulites. Under specific experimental conditions, amyloid spherulites are recognized as a significant component occurring in several protein model systems used for in vitro fibrillation studies. The state of the art is discussed together with some of the recent experimental results addressing the effect of specific factors on the growth of spherulites in solutions of bovine insulin. Moreover, future perspectives and ideas for a deeper characterization of this amyloid structure are also reported.

AB - In this chapter we discuss the possibility for proteins to self-assemble in large-scale amyloid aggregates of spherical shape termed amyloid spherulites. Under specific experimental conditions, amyloid spherulites are recognized as a significant component occurring in several protein model systems used for in vitro fibrillation studies. The state of the art is discussed together with some of the recent experimental results addressing the effect of specific factors on the growth of spherulites in solutions of bovine insulin. Moreover, future perspectives and ideas for a deeper characterization of this amyloid structure are also reported.

U2 - 10.1016/B978-0-12-394431-3.00028-6

DO - 10.1016/B978-0-12-394431-3.00028-6

M3 - Book chapter

SP - 301

EP - 308

BT - Bio-nanoimaging

A2 - Uversky, Vladimir

A2 - Lyubchenko , Yuri

PB - Academic Press

ER -