The etiology of multiple sclerosis: genetic evidence for the involvement of the human endogenous retrovirus HERV-Fc1

Bjørn Andersen Nexø; Tove Christensen; Jette Frederiksen; Anné Møller-Larsen; Annette B Oturai; Palle Villesen Fredsted; Bettina Hansen; Kari Konstantin Nissen; Magdalena Janina Laska; Trine Skov Petersen; Sandra Bonnesen; Anne Hedemand; Tingting Wu; Xinjie Wang; Xiuqing Zhang; Tomasz Brudek; Romana Maric; Helle B Søndergaard; Finn Sellebjerg; Klaus Brusgaard; Anders Langfelt Kjeldbjerg; Henrik B Rasmussen; Anders L Nielsen; Mette Nyegaard; Thor Petersen; Anders Børglum; Finn Skou Pedersen

doi:10.1371/journal.pone.0016652

The etiology of multiple sclerosis: genetic evidence for the involvement of the human endogenous retrovirus HERV-Fc1

Bjørn Andersen Nexø, Tove Christensen, Jette Frederiksen, Anné Møller-Larsen, Annette B Oturai, Palle Villesen Fredsted, Bettina Hansen, Kari Konstantin Nissen, Magdalena Janina Laska, Trine Skov Petersen, Sandra Bonnesen, Anne Hedemand, Tingting Wu, Xinjie Wang, Xiuqing Zhang, Tomasz Brudek, Romana Maric, Helle B Søndergaard, Finn Sellebjerg, Klaus BrusgaardAnders Langfelt Kjeldbjerg, Henrik B Rasmussen, Anders L Nielsen, Mette Nyegaard, Thor Petersen, Anders Børglum, Finn Skou Pedersen

Department of Clinical Medicine

52 Citations (Scopus)

Abstract

We have investigated the role of human endogenous retroviruses in multiple sclerosis by analyzing the DNA of patients and controls in 4 cohorts for associations between multiple sclerosis and polymorphisms near viral restriction genes or near endogenous retroviral loci with one or more intact or almost-intact genes. We found that SNPs in the gene TRIM5 were inversely correlated with disease. Conversely, SNPs around one retroviral locus, HERV-Fc1, showed a highly significant association with disease. The latter association was limited to a narrow region that contains no other known genes. We conclude that HERV-Fc1 and TRIM5 play a role in the etiology of multiple sclerosis. If these results are confirmed, they point to new modes of treatment for multiple sclerosis.

Original language	English
Journal	P L o S One
Volume	6
Issue number	2
Pages (from-to)	e16652
Number of pages	5
ISSN	1932-6203
DOIs	https://doi.org/10.1371/journal.pone.0016652 https://doi.org/10.1371/journal.pone.0016652
Publication status	Published - 1 Feb 2011

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Nexø, B. A., Christensen, T., Frederiksen, J., Møller-Larsen, A., Oturai, A. B., Fredsted, P. V., Hansen, B., Nissen, K. K., Laska, M. J., Petersen, T. S., Bonnesen, S., Hedemand, A., Wu, T., Wang, X., Zhang, X., Brudek, T., Maric, R., Søndergaard, H. B., Sellebjerg, F., ... Pedersen, F. S. (2011). The etiology of multiple sclerosis: genetic evidence for the involvement of the human endogenous retrovirus HERV-Fc1. P L o S One, 6(2), e16652. https://doi.org/10.1371/journal.pone.0016652, https://doi.org/10.1371/journal.pone.0016652

Nexø, BA, Christensen, T, Frederiksen, J, Møller-Larsen, A, Oturai, AB, Fredsted, PV, Hansen, B, Nissen, KK, Laska, MJ, Petersen, TS, Bonnesen, S, Hedemand, A, Wu, T, Wang, X, Zhang, X, Brudek, T, Maric, R, Søndergaard, HB, Sellebjerg, F, Brusgaard, K, Kjeldbjerg, AL, Rasmussen, HB, Nielsen, AL, Nyegaard, M, Petersen, T, Børglum, A & Pedersen, FS 2011, 'The etiology of multiple sclerosis: genetic evidence for the involvement of the human endogenous retrovirus HERV-Fc1', P L o S One, vol. 6, no. 2, pp. e16652. https://doi.org/10.1371/journal.pone.0016652, https://doi.org/10.1371/journal.pone.0016652

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abstract = "We have investigated the role of human endogenous retroviruses in multiple sclerosis by analyzing the DNA of patients and controls in 4 cohorts for associations between multiple sclerosis and polymorphisms near viral restriction genes or near endogenous retroviral loci with one or more intact or almost-intact genes. We found that SNPs in the gene TRIM5 were inversely correlated with disease. Conversely, SNPs around one retroviral locus, HERV-Fc1, showed a highly significant association with disease. The latter association was limited to a narrow region that contains no other known genes. We conclude that HERV-Fc1 and TRIM5 play a role in the etiology of multiple sclerosis. If these results are confirmed, they point to new modes of treatment for multiple sclerosis.",

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AU - Nexø, Bjørn Andersen

AU - Christensen, Tove

AU - Frederiksen, Jette

AU - Møller-Larsen, Anné

AU - Oturai, Annette B

AU - Fredsted, Palle Villesen

AU - Hansen, Bettina

AU - Nissen, Kari Konstantin

AU - Laska, Magdalena Janina

AU - Petersen, Trine Skov

AU - Bonnesen, Sandra

AU - Hedemand, Anne

AU - Wu, Tingting

AU - Wang, Xinjie

AU - Zhang, Xiuqing

AU - Brudek, Tomasz

AU - Maric, Romana

AU - Søndergaard, Helle B

AU - Sellebjerg, Finn

AU - Brusgaard, Klaus

AU - Kjeldbjerg, Anders Langfelt

AU - Rasmussen, Henrik B

AU - Nielsen, Anders L

AU - Nyegaard, Mette

AU - Petersen, Thor

AU - Børglum, Anders

AU - Pedersen, Finn Skou

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N2 - We have investigated the role of human endogenous retroviruses in multiple sclerosis by analyzing the DNA of patients and controls in 4 cohorts for associations between multiple sclerosis and polymorphisms near viral restriction genes or near endogenous retroviral loci with one or more intact or almost-intact genes. We found that SNPs in the gene TRIM5 were inversely correlated with disease. Conversely, SNPs around one retroviral locus, HERV-Fc1, showed a highly significant association with disease. The latter association was limited to a narrow region that contains no other known genes. We conclude that HERV-Fc1 and TRIM5 play a role in the etiology of multiple sclerosis. If these results are confirmed, they point to new modes of treatment for multiple sclerosis.

AB - We have investigated the role of human endogenous retroviruses in multiple sclerosis by analyzing the DNA of patients and controls in 4 cohorts for associations between multiple sclerosis and polymorphisms near viral restriction genes or near endogenous retroviral loci with one or more intact or almost-intact genes. We found that SNPs in the gene TRIM5 were inversely correlated with disease. Conversely, SNPs around one retroviral locus, HERV-Fc1, showed a highly significant association with disease. The latter association was limited to a narrow region that contains no other known genes. We conclude that HERV-Fc1 and TRIM5 play a role in the etiology of multiple sclerosis. If these results are confirmed, they point to new modes of treatment for multiple sclerosis.

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DO - 10.1371/journal.pone.0016652

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JO - P L o S One

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ER -

The etiology of multiple sclerosis: genetic evidence for the involvement of the human endogenous retrovirus HERV-Fc1

Abstract

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