The etiology of multiple sclerosis: genetic evidence for the involvement of the human endogenous retrovirus HERV-Fc1

Bjørn Andersen Nexø; Tove Christensen; Jette Frederiksen; Anné Møller-Larsen; Annette B Oturai; Palle Villesen Fredsted; Bettina Hansen; Kari Konstantin Nissen; Magdalena Janina Laska; Trine Skov Petersen; Sandra Bonnesen; Anne Hedemand; Tingting Wu; Xinjie Wang; Xiuqing Zhang; Tomasz Brudek; Romana Maric; Helle B Søndergaard; Finn Sellebjerg; Klaus Brusgaard; Anders Langfelt Kjeldbjerg; Henrik B Rasmussen; Anders L Nielsen; Mette Nyegaard; Thor Petersen; Anders Børglum; Finn Skou Pedersen

doi:10.1371/journal.pone.0016652

The etiology of multiple sclerosis: genetic evidence for the involvement of the human endogenous retrovirus HERV-Fc1

Bjørn Andersen Nexø, Tove Christensen, Jette Frederiksen, Anné Møller-Larsen, Annette B Oturai, Palle Villesen Fredsted, Bettina Hansen, Kari Konstantin Nissen, Magdalena Janina Laska, Trine Skov Petersen, Sandra Bonnesen, Anne Hedemand, Tingting Wu, Xinjie Wang, Xiuqing Zhang, Tomasz Brudek, Romana Maric, Helle B Søndergaard, Finn Sellebjerg, Klaus BrusgaardAnders Langfelt Kjeldbjerg, Henrik B Rasmussen, Anders L Nielsen, Mette Nyegaard, Thor Petersen, Anders Børglum, Finn Skou Pedersen

Department of Clinical Medicine

52 Citations (Scopus)

Abstract

We have investigated the role of human endogenous retroviruses in multiple sclerosis by analyzing the DNA of patients and controls in 4 cohorts for associations between multiple sclerosis and polymorphisms near viral restriction genes or near endogenous retroviral loci with one or more intact or almost-intact genes. We found that SNPs in the gene TRIM5 were inversely correlated with disease. Conversely, SNPs around one retroviral locus, HERV-Fc1, showed a highly significant association with disease. The latter association was limited to a narrow region that contains no other known genes. We conclude that HERV-Fc1 and TRIM5 play a role in the etiology of multiple sclerosis. If these results are confirmed, they point to new modes of treatment for multiple sclerosis.

Original language	English
Journal	P L o S One
Volume	6
Issue number	2
Pages (from-to)	e16652
Number of pages	5
ISSN	1932-6203
DOIs	https://doi.org/10.1371/journal.pone.0016652 https://doi.org/10.1371/journal.pone.0016652
Publication status	Published - 1 Feb 2011

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

Cite this

Nexø, B. A., Christensen, T., Frederiksen, J., Møller-Larsen, A., Oturai, A. B., Fredsted, P. V., Hansen, B., Nissen, K. K., Laska, M. J., Petersen, T. S., Bonnesen, S., Hedemand, A., Wu, T., Wang, X., Zhang, X., Brudek, T., Maric, R., Søndergaard, H. B., Sellebjerg, F., ... Pedersen, F. S. (2011). The etiology of multiple sclerosis: genetic evidence for the involvement of the human endogenous retrovirus HERV-Fc1. P L o S One, 6(2), e16652. https://doi.org/10.1371/journal.pone.0016652, https://doi.org/10.1371/journal.pone.0016652

Nexø, BA, Christensen, T, Frederiksen, J, Møller-Larsen, A, Oturai, AB, Fredsted, PV, Hansen, B, Nissen, KK, Laska, MJ, Petersen, TS, Bonnesen, S, Hedemand, A, Wu, T, Wang, X, Zhang, X, Brudek, T, Maric, R, Søndergaard, HB, Sellebjerg, F, Brusgaard, K, Kjeldbjerg, AL, Rasmussen, HB, Nielsen, AL, Nyegaard, M, Petersen, T, Børglum, A & Pedersen, FS 2011, 'The etiology of multiple sclerosis: genetic evidence for the involvement of the human endogenous retrovirus HERV-Fc1', P L o S One, vol. 6, no. 2, pp. e16652. https://doi.org/10.1371/journal.pone.0016652, https://doi.org/10.1371/journal.pone.0016652

@article{8a7f5a960a6647e5ba175afbc63e285c,

title = "The etiology of multiple sclerosis: genetic evidence for the involvement of the human endogenous retrovirus HERV-Fc1",

abstract = "We have investigated the role of human endogenous retroviruses in multiple sclerosis by analyzing the DNA of patients and controls in 4 cohorts for associations between multiple sclerosis and polymorphisms near viral restriction genes or near endogenous retroviral loci with one or more intact or almost-intact genes. We found that SNPs in the gene TRIM5 were inversely correlated with disease. Conversely, SNPs around one retroviral locus, HERV-Fc1, showed a highly significant association with disease. The latter association was limited to a narrow region that contains no other known genes. We conclude that HERV-Fc1 and TRIM5 play a role in the etiology of multiple sclerosis. If these results are confirmed, they point to new modes of treatment for multiple sclerosis.",

author = "Nex{\o}, {Bj{\o}rn Andersen} and Tove Christensen and Jette Frederiksen and Ann{\'e} M{\o}ller-Larsen and Oturai, {Annette B} and Fredsted, {Palle Villesen} and Bettina Hansen and Nissen, {Kari Konstantin} and Laska, {Magdalena Janina} and Petersen, {Trine Skov} and Sandra Bonnesen and Anne Hedemand and Tingting Wu and Xinjie Wang and Xiuqing Zhang and Tomasz Brudek and Romana Maric and S{\o}ndergaard, {Helle B} and Finn Sellebjerg and Klaus Brusgaard and Kjeldbjerg, {Anders Langfelt} and Rasmussen, {Henrik B} and Nielsen, {Anders L} and Mette Nyegaard and Thor Petersen and Anders B{\o}rglum and Pedersen, {Finn Skou}",

year = "2011",

month = feb,

day = "1",

doi = "10.1371/journal.pone.0016652",

language = "English",

volume = "6",

pages = "e16652",

journal = "PLoS Computational Biology",

issn = "1932-6203",

publisher = "Public Library of Science",

number = "2",

}

TY - JOUR

T1 - The etiology of multiple sclerosis: genetic evidence for the involvement of the human endogenous retrovirus HERV-Fc1

AU - Nexø, Bjørn Andersen

AU - Christensen, Tove

AU - Frederiksen, Jette

AU - Møller-Larsen, Anné

AU - Oturai, Annette B

AU - Fredsted, Palle Villesen

AU - Hansen, Bettina

AU - Nissen, Kari Konstantin

AU - Laska, Magdalena Janina

AU - Petersen, Trine Skov

AU - Bonnesen, Sandra

AU - Hedemand, Anne

AU - Wu, Tingting

AU - Wang, Xinjie

AU - Zhang, Xiuqing

AU - Brudek, Tomasz

AU - Maric, Romana

AU - Søndergaard, Helle B

AU - Sellebjerg, Finn

AU - Brusgaard, Klaus

AU - Kjeldbjerg, Anders Langfelt

AU - Rasmussen, Henrik B

AU - Nielsen, Anders L

AU - Nyegaard, Mette

AU - Petersen, Thor

AU - Børglum, Anders

AU - Pedersen, Finn Skou

PY - 2011/2/1

Y1 - 2011/2/1

N2 - We have investigated the role of human endogenous retroviruses in multiple sclerosis by analyzing the DNA of patients and controls in 4 cohorts for associations between multiple sclerosis and polymorphisms near viral restriction genes or near endogenous retroviral loci with one or more intact or almost-intact genes. We found that SNPs in the gene TRIM5 were inversely correlated with disease. Conversely, SNPs around one retroviral locus, HERV-Fc1, showed a highly significant association with disease. The latter association was limited to a narrow region that contains no other known genes. We conclude that HERV-Fc1 and TRIM5 play a role in the etiology of multiple sclerosis. If these results are confirmed, they point to new modes of treatment for multiple sclerosis.

AB - We have investigated the role of human endogenous retroviruses in multiple sclerosis by analyzing the DNA of patients and controls in 4 cohorts for associations between multiple sclerosis and polymorphisms near viral restriction genes or near endogenous retroviral loci with one or more intact or almost-intact genes. We found that SNPs in the gene TRIM5 were inversely correlated with disease. Conversely, SNPs around one retroviral locus, HERV-Fc1, showed a highly significant association with disease. The latter association was limited to a narrow region that contains no other known genes. We conclude that HERV-Fc1 and TRIM5 play a role in the etiology of multiple sclerosis. If these results are confirmed, they point to new modes of treatment for multiple sclerosis.

U2 - 10.1371/journal.pone.0016652

DO - 10.1371/journal.pone.0016652

M3 - Journal article

SN - 1932-6203

VL - 6

SP - e16652

JO - PLoS Computational Biology

JF - PLoS Computational Biology

IS - 2

ER -

The etiology of multiple sclerosis: genetic evidence for the involvement of the human endogenous retrovirus HERV-Fc1

Abstract

UN SDGs

Access to Document

Fingerprint

Cite this