Abstract
Epidermal growth factor (EGF) is synthesized as a membrane bound precursor in the rat kidney. The precursor seems to be processed by an aprotinin sensitive proteinase. Intravenous infusion of aprotinin reduces the urinary excretion of EGF by 85% and increases the amount of renal EGF. Kidney membranes incubated at 37 degrees C release EGF and this release is inhibited by aprotinin.
| Original language | English |
|---|---|
| Journal | Agents and actions. Supplements |
| Volume | 38 ( Pt 2) |
| Pages (from-to) | 183-90 |
| Number of pages | 8 |
| ISSN | 0379-0363 |
| Publication status | Published - 1992 |
Keywords
- Amino Acid Sequence
- Animals
- Aprotinin
- Autoradiography
- Cell Membrane
- Endopeptidases
- Epidermal Growth Factor
- Female
- Iodine Radioisotopes
- Kidney
- Male
- Microvilli
- Protein Precursors
- Protein Processing, Post-Translational
- Rats
- Rats, Wistar
- Substrate Specificity