The Emerging Role of Epigenetics in Inflammation and Immunometabolism

Sukanya Raghuraman; Ida Donkin; Soetkin Versteyhe; Romain Barrès; David Simar

doi:10.1016/j.tem.2016.06.008

The Emerging Role of Epigenetics in Inflammation and Immunometabolism

Sukanya Raghuraman, Ida Donkin, Soetkin Versteyhe, Romain Barrès, David Simar

49 Citations (Scopus)

Abstract

Recent research developments have shed light on the risk factors contributing to metabolic complications, implicating both genetic and environmental factors, potentially integrated by epigenetic mechanisms. Distinct epigenetic changes in immune cells are frequently observed in obesity and type 2 diabetes mellitus, and these are associated with alterations in the phenotype, function, and trafficking patterns of these cells. The first step in the development of effective therapeutic strategies is the identification of distinct epigenetic signatures associated with metabolic disorders. In this review we provide an overview of the epigenetic mechanisms influencing immune cell phenotype and function, summarize current knowledge about epigenetic changes affecting immune functions in the context of metabolic diseases, and discuss the therapeutic options currently available to counteract epigenetically driven metabolic complications.

Original language	English
Journal	Trends in Endocrinology and Metabolism
Volume	27
Issue number	11
Pages (from-to)	782-795
Number of pages	14
ISSN	1043-2760
DOIs	https://doi.org/10.1016/j.tem.2016.06.008
Publication status	Published - 1 Nov 2016

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10.1016/j.tem.2016.06.008

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abstract = "Recent research developments have shed light on the risk factors contributing to metabolic complications, implicating both genetic and environmental factors, potentially integrated by epigenetic mechanisms. Distinct epigenetic changes in immune cells are frequently observed in obesity and type 2 diabetes mellitus, and these are associated with alterations in the phenotype, function, and trafficking patterns of these cells. The first step in the development of effective therapeutic strategies is the identification of distinct epigenetic signatures associated with metabolic disorders. In this review we provide an overview of the epigenetic mechanisms influencing immune cell phenotype and function, summarize current knowledge about epigenetic changes affecting immune functions in the context of metabolic diseases, and discuss the therapeutic options currently available to counteract epigenetically driven metabolic complications.",

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AU - Donkin, Ida

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AU - Barrès, Romain

AU - Simar, David

PY - 2016/11/1

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AB - Recent research developments have shed light on the risk factors contributing to metabolic complications, implicating both genetic and environmental factors, potentially integrated by epigenetic mechanisms. Distinct epigenetic changes in immune cells are frequently observed in obesity and type 2 diabetes mellitus, and these are associated with alterations in the phenotype, function, and trafficking patterns of these cells. The first step in the development of effective therapeutic strategies is the identification of distinct epigenetic signatures associated with metabolic disorders. In this review we provide an overview of the epigenetic mechanisms influencing immune cell phenotype and function, summarize current knowledge about epigenetic changes affecting immune functions in the context of metabolic diseases, and discuss the therapeutic options currently available to counteract epigenetically driven metabolic complications.

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The Emerging Role of Epigenetics in Inflammation and Immunometabolism

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