The Emerging Role of Epigenetics in Inflammation and Immunometabolism

TY - JOUR

T1 - The Emerging Role of Epigenetics in Inflammation and Immunometabolism

AU - Raghuraman, Sukanya

AU - Donkin, Ida

AU - Versteyhe, Soetkin

AU - Barrès, Romain

AU - Simar, David

N1 - Copyright © 2016 Elsevier Ltd. All rights reserved.

PY - 2016/11/1

Y1 - 2016/11/1

N2 - Recent research developments have shed light on the risk factors contributing to metabolic complications, implicating both genetic and environmental factors, potentially integrated by epigenetic mechanisms. Distinct epigenetic changes in immune cells are frequently observed in obesity and type 2 diabetes mellitus, and these are associated with alterations in the phenotype, function, and trafficking patterns of these cells. The first step in the development of effective therapeutic strategies is the identification of distinct epigenetic signatures associated with metabolic disorders. In this review we provide an overview of the epigenetic mechanisms influencing immune cell phenotype and function, summarize current knowledge about epigenetic changes affecting immune functions in the context of metabolic diseases, and discuss the therapeutic options currently available to counteract epigenetically driven metabolic complications.

AB - Recent research developments have shed light on the risk factors contributing to metabolic complications, implicating both genetic and environmental factors, potentially integrated by epigenetic mechanisms. Distinct epigenetic changes in immune cells are frequently observed in obesity and type 2 diabetes mellitus, and these are associated with alterations in the phenotype, function, and trafficking patterns of these cells. The first step in the development of effective therapeutic strategies is the identification of distinct epigenetic signatures associated with metabolic disorders. In this review we provide an overview of the epigenetic mechanisms influencing immune cell phenotype and function, summarize current knowledge about epigenetic changes affecting immune functions in the context of metabolic diseases, and discuss the therapeutic options currently available to counteract epigenetically driven metabolic complications.

U2 - 10.1016/j.tem.2016.06.008

DO - 10.1016/j.tem.2016.06.008

M3 - Review

C2 - 27444065

SN - 1043-2760

VL - 27

SP - 782

EP - 795

JO - Trends in Endocrinology and Metabolism

JF - Trends in Endocrinology and Metabolism

IS - 11

ER -