The EH network.

E Santolini; A E Salcini; B K Kay; M Yamabhai; P P Di Fiore

doi:10.1006/excr.1999.4694

The EH network.

E Santolini, A E Salcini, B K Kay, M Yamabhai, P P Di Fiore

115 Citations (Scopus)

Abstract

The EH domain is an evolutionary conserved protein-protein interaction domain present in a growing number of proteins from yeast to mammals. Even though the domain was discovered just 5 years ago, a great deal has been learned regarding its three-dimensional structure and binding specificities. Moreover, a number of cellular ligands of the domain have been identified and demonstrated to define a complex network of protein-protein interactions in the eukaryotic cell. Interestingly, many of the EH-containing and EH-binding proteins display characteristics of endocytic "accessory" proteins, suggesting that the principal function of the EH network is to regulate various steps in endocytosis. In addition, recent evidence suggests that the EH network might work as an "integrator" of signals controlling cellular pathways as diverse as endocytosis, nucleocytosolic export, and ultimately cell proliferation.

Original language	English
Journal	Experimental Cell Research
Volume	253
Issue number	1
Pages (from-to)	186-209
Number of pages	23
ISSN	0014-4827
DOIs	https://doi.org/10.1006/excr.1999.4694
Publication status	Published - 1999

Access to Document

10.1006/excr.1999.4694

Cite this

@article{82614890519a11dd8d9f000ea68e967b,

title = "The EH network.",

abstract = "The EH domain is an evolutionary conserved protein-protein interaction domain present in a growing number of proteins from yeast to mammals. Even though the domain was discovered just 5 years ago, a great deal has been learned regarding its three-dimensional structure and binding specificities. Moreover, a number of cellular ligands of the domain have been identified and demonstrated to define a complex network of protein-protein interactions in the eukaryotic cell. Interestingly, many of the EH-containing and EH-binding proteins display characteristics of endocytic {"}accessory{"} proteins, suggesting that the principal function of the EH network is to regulate various steps in endocytosis. In addition, recent evidence suggests that the EH network might work as an {"}integrator{"} of signals controlling cellular pathways as diverse as endocytosis, nucleocytosolic export, and ultimately cell proliferation.",

author = "E Santolini and Salcini, {A E} and Kay, {B K} and M Yamabhai and {Di Fiore}, {P P}",

note = "Keywords: Binding Sites; Biological Transport; Calcium-Binding Proteins; Endocytosis; Phosphoproteins; Protein Binding; Protein Structure, Tertiary",

year = "1999",

doi = "10.1006/excr.1999.4694",

language = "English",

volume = "253",

pages = "186--209",

journal = "Experimental Cell Research",

issn = "0014-4827",

publisher = "Academic Press",

number = "1",

}

TY - JOUR

T1 - The EH network.

AU - Santolini, E

AU - Salcini, A E

AU - Kay, B K

AU - Yamabhai, M

AU - Di Fiore, P P

N1 - Keywords: Binding Sites; Biological Transport; Calcium-Binding Proteins; Endocytosis; Phosphoproteins; Protein Binding; Protein Structure, Tertiary

PY - 1999

Y1 - 1999

N2 - The EH domain is an evolutionary conserved protein-protein interaction domain present in a growing number of proteins from yeast to mammals. Even though the domain was discovered just 5 years ago, a great deal has been learned regarding its three-dimensional structure and binding specificities. Moreover, a number of cellular ligands of the domain have been identified and demonstrated to define a complex network of protein-protein interactions in the eukaryotic cell. Interestingly, many of the EH-containing and EH-binding proteins display characteristics of endocytic "accessory" proteins, suggesting that the principal function of the EH network is to regulate various steps in endocytosis. In addition, recent evidence suggests that the EH network might work as an "integrator" of signals controlling cellular pathways as diverse as endocytosis, nucleocytosolic export, and ultimately cell proliferation.

AB - The EH domain is an evolutionary conserved protein-protein interaction domain present in a growing number of proteins from yeast to mammals. Even though the domain was discovered just 5 years ago, a great deal has been learned regarding its three-dimensional structure and binding specificities. Moreover, a number of cellular ligands of the domain have been identified and demonstrated to define a complex network of protein-protein interactions in the eukaryotic cell. Interestingly, many of the EH-containing and EH-binding proteins display characteristics of endocytic "accessory" proteins, suggesting that the principal function of the EH network is to regulate various steps in endocytosis. In addition, recent evidence suggests that the EH network might work as an "integrator" of signals controlling cellular pathways as diverse as endocytosis, nucleocytosolic export, and ultimately cell proliferation.

U2 - 10.1006/excr.1999.4694

DO - 10.1006/excr.1999.4694

M3 - Journal article

C2 - 10579923

SN - 0014-4827

VL - 253

SP - 186

EP - 209

JO - Experimental Cell Research

JF - Experimental Cell Research

IS - 1

ER -

The EH network.

Abstract

Access to Document

Fingerprint

Cite this