@article{82614890519a11dd8d9f000ea68e967b,
title = "The EH network.",
abstract = "The EH domain is an evolutionary conserved protein-protein interaction domain present in a growing number of proteins from yeast to mammals. Even though the domain was discovered just 5 years ago, a great deal has been learned regarding its three-dimensional structure and binding specificities. Moreover, a number of cellular ligands of the domain have been identified and demonstrated to define a complex network of protein-protein interactions in the eukaryotic cell. Interestingly, many of the EH-containing and EH-binding proteins display characteristics of endocytic {"}accessory{"} proteins, suggesting that the principal function of the EH network is to regulate various steps in endocytosis. In addition, recent evidence suggests that the EH network might work as an {"}integrator{"} of signals controlling cellular pathways as diverse as endocytosis, nucleocytosolic export, and ultimately cell proliferation.",
author = "E Santolini and Salcini, {A E} and Kay, {B K} and M Yamabhai and {Di Fiore}, {P P}",
note = "Keywords: Binding Sites; Biological Transport; Calcium-Binding Proteins; Endocytosis; Phosphoproteins; Protein Binding; Protein Structure, Tertiary",
year = "1999",
doi = "10.1006/excr.1999.4694",
language = "English",
volume = "253",
pages = "186--209",
journal = "Experimental Cell Research",
issn = "0014-4827",
publisher = "Academic Press",
number = "1",
}