Abstract
Objective: Recent research suggests that other surrogate markers than QTc, including QTc dispersion and Tpeak-Tend, may better correlate with cardiac arrhythmia risk. While sertindole significantly prolongs the QTc interval, the effects on other markers of arrhythmia risk, such as QTc dispersion and Tpeak-Tend are unknown. Method: Digital 12-lead ECG was recorded at baseline and at steady-state in 37 patients switched to sertindole. ECG was analysed for Fridericia-corrected QT duration (QTcF), QT dispersion and Tpeak-Tend. Results: From a baseline QTcF of 407 ± 22 ms, mean QTcF prolongation during sertindole treatment was 20 ± 23 ms, P < 0.01. No effect on QTc dispersion was found (-1 ± 11 ms; P = 0.41). No increased duration of the Tpeak-Tend interval from baseline was found (+7 ± 21 ms; P = 0.05). Conclusion: These findings might be related to the absence of confirmed Torsade de Pointes (TdP) cases related to sertindole exposure, despite sertindole's QTc prolonging effects.
| Original language | English |
|---|---|
| Book series | Acta Psychiatrica Scandinavica. Supplementum |
| Volume | 121 |
| Issue number | 5 |
| Pages (from-to) | 385-8 |
| Number of pages | 4 |
| ISSN | 0065-1591 |
| DOIs | |
| Publication status | Published - 1 May 2010 |
Keywords
- Adult
- Antipsychotic Agents
- Denmark
- Electrocardiography
- Female
- Heart Rate
- Humans
- Imidazoles
- Indoles
- Long QT Syndrome
- Male
- Middle Aged
- Prospective Studies
- Safety-Based Drug Withdrawals
- Schizophrenia
- Signal Processing, Computer-Assisted
- Torsades de Pointes