The effect of sertindole on QTD and TPTE

J Nielsen; M P Andersen; Claus Graff; Jørgen K. Kanters; Thomas Bork Hardahl; J Dybbro; Johannes J. Struijk; J M Meyer; E Toft

doi:10.1111/j.1600-0447.2009.01534.x

The effect of sertindole on QTD and TPTE

J Nielsen, M P Andersen, Claus Graff, Jørgen K. Kanters, Thomas Bork Hardahl, J Dybbro, Johannes J. Struijk, J M Meyer, E Toft

Physiology of circulation, kidney and lung

31 Citationer (Scopus)

Abstract

Objective: Recent research suggests that other surrogate markers than QTc, including QTc dispersion and Tpeak-Tend, may better correlate with cardiac arrhythmia risk. While sertindole significantly prolongs the QTc interval, the effects on other markers of arrhythmia risk, such as QTc dispersion and Tpeak-Tend are unknown. Method: Digital 12-lead ECG was recorded at baseline and at steady-state in 37 patients switched to sertindole. ECG was analysed for Fridericia-corrected QT duration (QTcF), QT dispersion and Tpeak-Tend. Results: From a baseline QTcF of 407 ± 22 ms, mean QTcF prolongation during sertindole treatment was 20 ± 23 ms, P < 0.01. No effect on QTc dispersion was found (-1 ± 11 ms; P = 0.41). No increased duration of the Tpeak-Tend interval from baseline was found (+7 ± 21 ms; P = 0.05). Conclusion: These findings might be related to the absence of confirmed Torsade de Pointes (TdP) cases related to sertindole exposure, despite sertindole's QTc prolonging effects.

Originalsprog	Engelsk
Bogserie	Acta Psychiatrica Scandinavica. Supplementum
Vol/bind	121
Udgave nummer	5
Sider (fra-til)	385-8
Antal sider	4
ISSN	0065-1591
DOI	https://doi.org/10.1111/j.1600-0447.2009.01534.x
Status	Udgivet - 1 maj 2010

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10.1111/j.1600-0447.2009.01534.x

Citationsformater

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abstract = "Objective: Recent research suggests that other surrogate markers than QTc, including QTc dispersion and Tpeak-Tend, may better correlate with cardiac arrhythmia risk. While sertindole significantly prolongs the QTc interval, the effects on other markers of arrhythmia risk, such as QTc dispersion and Tpeak-Tend are unknown. Method: Digital 12-lead ECG was recorded at baseline and at steady-state in 37 patients switched to sertindole. ECG was analysed for Fridericia-corrected QT duration (QTcF), QT dispersion and Tpeak-Tend. Results: From a baseline QTcF of 407 ± 22 ms, mean QTcF prolongation during sertindole treatment was 20 ± 23 ms, P < 0.01. No effect on QTc dispersion was found (-1 ± 11 ms; P = 0.41). No increased duration of the Tpeak-Tend interval from baseline was found (+7 ± 21 ms; P = 0.05). Conclusion: These findings might be related to the absence of confirmed Torsade de Pointes (TdP) cases related to sertindole exposure, despite sertindole's QTc prolonging effects.",

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AU - Nielsen, J

AU - Andersen, M P

AU - Graff, Claus

AU - Kanters, Jørgen K.

AU - Hardahl, Thomas Bork

AU - Dybbro, J

AU - Struijk, Johannes J.

AU - Meyer, J M

AU - Toft, E

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N2 - Objective: Recent research suggests that other surrogate markers than QTc, including QTc dispersion and Tpeak-Tend, may better correlate with cardiac arrhythmia risk. While sertindole significantly prolongs the QTc interval, the effects on other markers of arrhythmia risk, such as QTc dispersion and Tpeak-Tend are unknown. Method: Digital 12-lead ECG was recorded at baseline and at steady-state in 37 patients switched to sertindole. ECG was analysed for Fridericia-corrected QT duration (QTcF), QT dispersion and Tpeak-Tend. Results: From a baseline QTcF of 407 ± 22 ms, mean QTcF prolongation during sertindole treatment was 20 ± 23 ms, P < 0.01. No effect on QTc dispersion was found (-1 ± 11 ms; P = 0.41). No increased duration of the Tpeak-Tend interval from baseline was found (+7 ± 21 ms; P = 0.05). Conclusion: These findings might be related to the absence of confirmed Torsade de Pointes (TdP) cases related to sertindole exposure, despite sertindole's QTc prolonging effects.

AB - Objective: Recent research suggests that other surrogate markers than QTc, including QTc dispersion and Tpeak-Tend, may better correlate with cardiac arrhythmia risk. While sertindole significantly prolongs the QTc interval, the effects on other markers of arrhythmia risk, such as QTc dispersion and Tpeak-Tend are unknown. Method: Digital 12-lead ECG was recorded at baseline and at steady-state in 37 patients switched to sertindole. ECG was analysed for Fridericia-corrected QT duration (QTcF), QT dispersion and Tpeak-Tend. Results: From a baseline QTcF of 407 ± 22 ms, mean QTcF prolongation during sertindole treatment was 20 ± 23 ms, P < 0.01. No effect on QTc dispersion was found (-1 ± 11 ms; P = 0.41). No increased duration of the Tpeak-Tend interval from baseline was found (+7 ± 21 ms; P = 0.05). Conclusion: These findings might be related to the absence of confirmed Torsade de Pointes (TdP) cases related to sertindole exposure, despite sertindole's QTc prolonging effects.

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KW - Antipsychotic Agents

KW - Denmark

KW - Electrocardiography

KW - Female

KW - Heart Rate

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KW - Imidazoles

KW - Indoles

KW - Long QT Syndrome

KW - Male

KW - Middle Aged

KW - Prospective Studies

KW - Safety-Based Drug Withdrawals

KW - Schizophrenia

KW - Signal Processing, Computer-Assisted

KW - Torsades de Pointes

U2 - 10.1111/j.1600-0447.2009.01534.x

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SP - 385

EP - 388

JO - Acta Psychiatrica Scandinavica, Supplement

JF - Acta Psychiatrica Scandinavica, Supplement

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ER -

The effect of sertindole on QTD and TPTE

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