TY - JOUR
T1 - The effect of high- to low-altitude adaptation on the multifocal electroretinogram
AU - Kofoed, Peter Kristian
AU - Sander, Birgit
AU - Zubieta-Calleja, Gustavo
AU - Kessel, Line
AU - Klemp, Kristian
AU - Larsen, Michael
AU - Kofoed, Peter Kristian
AU - Sander, Birgit
AU - Zubieta-Calleja, Gustavo
AU - Kessel, Line
AU - Klemp, Kristian
AU - Larsen, Michael
N1 - Keywords: Acclimatization; Adult; Altitude; Blood Glucose; Electroretinography; Erythrocyte Count; Female; Hematocrit; Hemoglobins; Humans; Intraocular Pressure; Male; Oxygen; Oxygen Consumption; Retina
PY - 2009/8/1
Y1 - 2009/8/1
N2 - PURPOSE: To examine variations in retinal electrophysiology assessed by multifocal electroretinogram (mfERG) during acclimatization of native highlanders to normobaric normoxia at sea level. METHODS: Eight healthy residents of the greater La Paz area in Bolivia (3600 m above sea level) were examined over 72 days after arriving in Copenhagen, Denmark (sea level). A control group of eight healthy lowlanders was used for comparison. RESULTS: During the period of observation, hemoglobin decreased from 16.7 to 15.0 g/dL (P = 0.0031), erythrocytes decreased from 5.3 to 4.6 trillion cells/L (P = 0.0006), and hematocrit decreased from 49.4% to 42.2% (P = 0.0008). At baseline, day 2 after arrival, the amplitudes (N1, P1, and N2) of the mfERG were 43.1% to 59.9% higher in the highlanders than in the lowlanders (P < 0.017). During acclimatization, the mfERG amplitudes increased 16.9% to 20.4% (P < 0.028) to a level of 73.2% to 87.0% higher in the highlanders than in the lowlanders (P < 0.0008). The increase in numerical amplitudes was proportional to the decrease in erythrocyte concentration (P = 0.023, 0.053, and 0.12 for N1, P1, and N2, respectively). CONCLUSIONS: On arrival at sea level, the highlanders had markedly supernormal multifocal electroretinographic amplitudes that continued to increase during the 72-day period of observation where the highlanders' hematocrit normalized. The results suggest that acclimatization after a change in altitude and hence in ambient oxygen tension involves intrinsic retinal mechanisms and that acclimatization was not complete by the end of the study.
AB - PURPOSE: To examine variations in retinal electrophysiology assessed by multifocal electroretinogram (mfERG) during acclimatization of native highlanders to normobaric normoxia at sea level. METHODS: Eight healthy residents of the greater La Paz area in Bolivia (3600 m above sea level) were examined over 72 days after arriving in Copenhagen, Denmark (sea level). A control group of eight healthy lowlanders was used for comparison. RESULTS: During the period of observation, hemoglobin decreased from 16.7 to 15.0 g/dL (P = 0.0031), erythrocytes decreased from 5.3 to 4.6 trillion cells/L (P = 0.0006), and hematocrit decreased from 49.4% to 42.2% (P = 0.0008). At baseline, day 2 after arrival, the amplitudes (N1, P1, and N2) of the mfERG were 43.1% to 59.9% higher in the highlanders than in the lowlanders (P < 0.017). During acclimatization, the mfERG amplitudes increased 16.9% to 20.4% (P < 0.028) to a level of 73.2% to 87.0% higher in the highlanders than in the lowlanders (P < 0.0008). The increase in numerical amplitudes was proportional to the decrease in erythrocyte concentration (P = 0.023, 0.053, and 0.12 for N1, P1, and N2, respectively). CONCLUSIONS: On arrival at sea level, the highlanders had markedly supernormal multifocal electroretinographic amplitudes that continued to increase during the 72-day period of observation where the highlanders' hematocrit normalized. The results suggest that acclimatization after a change in altitude and hence in ambient oxygen tension involves intrinsic retinal mechanisms and that acclimatization was not complete by the end of the study.
U2 - 10.1167/iovs.08-3216
DO - 10.1167/iovs.08-3216
M3 - Journal article
C2 - 19234353
SN - 0146-0404
VL - 50
SP - 3964
EP - 3969
JO - Investigative Ophthalmology & Visual Science
JF - Investigative Ophthalmology & Visual Science
IS - 8
ER -