The effect of beta-interferon therapy on myelin basic protein-elicited CD4+ T cell proliferation and cytokine production in multiple sclerosis

Chris J Hedegaard; Martin Krakauer; Klaus Bendtzen; Per Soelberg Sørensen; Finn Sellebjerg; Claus H Nielsen

doi:10.1016/j.clim.2008.06.007

The effect of beta-interferon therapy on myelin basic protein-elicited CD4+ T cell proliferation and cytokine production in multiple sclerosis

Chris J Hedegaard, Martin Krakauer, Klaus Bendtzen, Per Soelberg Sørensen, Finn Sellebjerg, Claus H Nielsen

Department of Clinical Medicine

12 Citations (Scopus)

Abstract

Interferon (IFN)-beta therapy has well-established clinical benefits in multiple sclerosis (MS), but the underlying modulation of cytokine responses to myelin self-antigens remains poorly understood. We analysed the CD4+ T cell proliferation and cytokine responses elicited by myelin basic protein (MBP) and a foreign recall antigen, tetanus toxoid (TT), in mononuclear cell cultures from fourteen MS patients undergoing IFN-beta therapy. The MBP-elicited IFN-gamma-, TNF-alpha- and IL-10 production decreased during therapy (p

Original language	English
Journal	Clinical Immunology
Volume	129
Issue number	1
Pages (from-to)	80-9
Number of pages	10
ISSN	1521-6616
DOIs	https://doi.org/10.1016/j.clim.2008.06.007 https://doi.org/10.1016/j.clim.2008.06.007
Publication status	Published - 1 Oct 2008

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Hedegaard, C. J., Krakauer, M., Bendtzen, K., Sørensen, P. S., Sellebjerg, F., & Nielsen, C. H. (2008). The effect of beta-interferon therapy on myelin basic protein-elicited CD4+ T cell proliferation and cytokine production in multiple sclerosis. Clinical Immunology, 129(1), 80-9. https://doi.org/10.1016/j.clim.2008.06.007, https://doi.org/10.1016/j.clim.2008.06.007

Hedegaard, CJ, Krakauer, M, Bendtzen, K, Sørensen, PS , Sellebjerg, F & Nielsen, CH 2008, 'The effect of beta-interferon therapy on myelin basic protein-elicited CD4+ T cell proliferation and cytokine production in multiple sclerosis', Clinical Immunology, vol. 129, no. 1, pp. 80-9. https://doi.org/10.1016/j.clim.2008.06.007, https://doi.org/10.1016/j.clim.2008.06.007

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AU - Sørensen, Per Soelberg

AU - Sellebjerg, Finn

AU - Nielsen, Claus H

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AB - Interferon (IFN)-beta therapy has well-established clinical benefits in multiple sclerosis (MS), but the underlying modulation of cytokine responses to myelin self-antigens remains poorly understood. We analysed the CD4+ T cell proliferation and cytokine responses elicited by myelin basic protein (MBP) and a foreign recall antigen, tetanus toxoid (TT), in mononuclear cell cultures from fourteen MS patients undergoing IFN-beta therapy. The MBP-elicited IFN-gamma-, TNF-alpha- and IL-10 production decreased during therapy (p

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The effect of beta-interferon therapy on myelin basic protein-elicited CD4+ T cell proliferation and cytokine production in multiple sclerosis

Abstract

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