The effect of beta-interferon therapy on myelin basic protein-elicited CD4+ T cell proliferation and cytokine production in multiple sclerosis

Chris J Hedegaard; Martin Krakauer; Klaus Bendtzen; Per Soelberg Sørensen; Finn Sellebjerg; Claus H Nielsen

doi:10.1016/j.clim.2008.06.007

The effect of beta-interferon therapy on myelin basic protein-elicited CD4+ T cell proliferation and cytokine production in multiple sclerosis

Chris J Hedegaard, Martin Krakauer, Klaus Bendtzen, Per Soelberg Sørensen, Finn Sellebjerg, Claus H Nielsen

Institut for Klinisk Medicin

12 Citationer (Scopus)

Abstract

Interferon (IFN)-beta therapy has well-established clinical benefits in multiple sclerosis (MS), but the underlying modulation of cytokine responses to myelin self-antigens remains poorly understood. We analysed the CD4+ T cell proliferation and cytokine responses elicited by myelin basic protein (MBP) and a foreign recall antigen, tetanus toxoid (TT), in mononuclear cell cultures from fourteen MS patients undergoing IFN-beta therapy. The MBP-elicited IFN-gamma-, TNF-alpha- and IL-10 production decreased during therapy (p<0.007-0.03), while the IL-6 production increased (p<0.03). No significant change was observed in the MBP-induced CD4+ T cell proliferation, or in the production of IL-4, IL-5 and brain-derived neurotrophic factor. In comparison, IFN-beta therapy reduced IFN-gamma and IL-4 responses to TT (p<0.003 and p<0.04). Thus, IFN-beta inhibits IFN-gamma production in general, presumably alleviating the detrimental influence of IFN-gamma in MS. However, the increase in proinflammatory IL-6 and the decrease in anti-inflammatory IL-10 responses suggest that IFN-beta has more diverse effects than previously assumed
Udgivelsesdato: 2008/10

Originalsprog	Engelsk
Tidsskrift	Clinical Immunology
Vol/bind	129
Udgave nummer	1
Sider (fra-til)	80-9
Antal sider	10
ISSN	1521-6616
DOI	https://doi.org/10.1016/j.clim.2008.06.007 https://doi.org/10.1016/j.clim.2008.06.007
Status	Udgivet - 1 okt. 2008

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Hedegaard, C. J., Krakauer, M., Bendtzen, K., Sørensen, P. S., Sellebjerg, F., & Nielsen, C. H. (2008). The effect of beta-interferon therapy on myelin basic protein-elicited CD4+ T cell proliferation and cytokine production in multiple sclerosis. Clinical Immunology, 129(1), 80-9. https://doi.org/10.1016/j.clim.2008.06.007, https://doi.org/10.1016/j.clim.2008.06.007

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AU - Hedegaard, Chris J

AU - Krakauer, Martin

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AU - Sørensen, Per Soelberg

AU - Sellebjerg, Finn

AU - Nielsen, Claus H

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AB - Interferon (IFN)-beta therapy has well-established clinical benefits in multiple sclerosis (MS), but the underlying modulation of cytokine responses to myelin self-antigens remains poorly understood. We analysed the CD4+ T cell proliferation and cytokine responses elicited by myelin basic protein (MBP) and a foreign recall antigen, tetanus toxoid (TT), in mononuclear cell cultures from fourteen MS patients undergoing IFN-beta therapy. The MBP-elicited IFN-gamma-, TNF-alpha- and IL-10 production decreased during therapy (p

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DO - 10.1016/j.clim.2008.06.007

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The effect of beta-interferon therapy on myelin basic protein-elicited CD4+ T cell proliferation and cytokine production in multiple sclerosis

Abstract

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