The effect of alternate-day caloric restriction on the metabolic consequences of 8 days of bed rest in healthy lean men: a randomized trial

Nina Majlund Harder-Lauridsen; Signe Tellerup Nielsen; Sebastian Porsdam Mann; Mark Preben Lyngbæk; Fabiana Braga Benatti; Annika Reynberg Langkilde; Ian Law; Anne-Sophie Wedell-Neergaard; Carsten Thomsen; Kirsten Møller; Kristian Karstoft; Bente Klarlund Pedersen; Rikke Krogh-Madsen

doi:10.1152/japplphysiol.00846.2016

The effect of alternate-day caloric restriction on the metabolic consequences of 8 days of bed rest in healthy lean men: a randomized trial

Nina Majlund Harder-Lauridsen, Signe Tellerup Nielsen, Sebastian Porsdam Mann, Mark Preben Lyngbæk, Fabiana Braga Benatti, Annika Reynberg Langkilde, Ian Law, Anne-Sophie Wedell-Neergaard, Carsten Thomsen, Kirsten Møller, Kristian Karstoft, Bente Klarlund Pedersen, Rikke Krogh-Madsen

Department of Clinical Medicine

11 Citations (Scopus)

Abstract

Physical activity and alternate-day fasting/caloric restriction may both ameliorate aspects of the metabolic syndrome, such as insulin resistance, visceral fat mass accumulation, and cognitive impairment by overlapping mechanisms. The purpose of this study was to test the hypothesis that alternate-day caloric restriction (ADCR) with overall energy balance would reduce insulin resistance and accumulation of visceral fat, in addition to improving cognitive functions, after 8 consecutive days in bed. Healthy, lean men (n = 20) were randomized to 1) 8 days of bed rest with three daily isoenergetic meals (control group, n = 10); and 2) 8 days of bed rest with 25% of total energy requirements every other day and 175% of total energy requirements every other day (ADCR group). Oral glucose tolerance testing, dual-energy X-ray absorptiometry (DXA) scans, magnetic resonance imaging of the abdomen and brain, V̇o2max, and tests for cognitive function were performed before and after bed rest. In addition, daily fasting blood samples and 24-h glucose profiles by continuous glucose monitoring system were assessed during the 8 days of bed rest period. Bed rest induced insulin resistance, visceral fat accumulation, and worsening of mood. No positive effects emerged from ADCR on these negative health outcomes. Compared with the control group, ADCR was associated with improved and steadier glycemic control on fasting days and higher glycemic fluctuation and indexes of insulin resistance on overeating days. In contrast to our hypothesis, the metabolic impairment induced by 8 days of bed rest was not counteracted by ADCR with overall energy balance.

NEW & NOTEWORTHY: Alternate-day caloric restriction without overall energy reduction does not ameliorate the metabolic impairment induced in lean men by 8 days of bed rest.

Original language	English
Journal	Journal of Applied Physiology
Volume	122
Issue number	2
Pages (from-to)	230-241
Number of pages	12
ISSN	8750-7587
DOIs	https://doi.org/10.1152/japplphysiol.00846.2016
Publication status	Published - Feb 2017

Keywords

Adult
Affect/physiology
Bed Rest/adverse effects
Blood Glucose/metabolism
Caloric Restriction/methods
Cognition/physiology
Energy Metabolism/physiology
Exercise/physiology
Fasting/physiology
Glucose/metabolism
Glucose Tolerance Test/methods
Humans
Insulin/metabolism
Insulin Resistance/physiology
Intra-Abdominal Fat/metabolism
Male
Metabolic Syndrome/metabolism
Young Adult

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10.1152/japplphysiol.00846.2016

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Harder-Lauridsen, N. M., Nielsen, S. T., Mann, S. P., Lyngbæk, M. P., Benatti, F. B., Langkilde, A. R., Law, I., Wedell-Neergaard, A.-S., Thomsen, C., Møller, K., Karstoft, K., Pedersen, B. K., & Krogh-Madsen, R. (2017). The effect of alternate-day caloric restriction on the metabolic consequences of 8 days of bed rest in healthy lean men: a randomized trial. Journal of Applied Physiology, 122(2), 230-241. https://doi.org/10.1152/japplphysiol.00846.2016

The effect of alternate-day caloric restriction on the metabolic consequences of 8 days of bed rest in healthy lean men: a randomized trial. / Harder-Lauridsen, Nina Majlund; Nielsen, Signe Tellerup; Mann, Sebastian Porsdam et al.
In: Journal of Applied Physiology, Vol. 122, No. 2, 02.2017, p. 230-241.

Research output: Contribution to journal › Journal article › Research › peer-review

Harder-Lauridsen, NM, Nielsen, ST, Mann, SP, Lyngbæk, MP, Benatti, FB, Langkilde, AR , Law, I, Wedell-Neergaard, A-S, Thomsen, C, Møller, K, Karstoft, K, Pedersen, BK & Krogh-Madsen, R 2017, 'The effect of alternate-day caloric restriction on the metabolic consequences of 8 days of bed rest in healthy lean men: a randomized trial', Journal of Applied Physiology, vol. 122, no. 2, pp. 230-241. https://doi.org/10.1152/japplphysiol.00846.2016

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abstract = "Physical activity and alternate-day fasting/caloric restriction may both ameliorate aspects of the metabolic syndrome, such as insulin resistance, visceral fat mass accumulation, and cognitive impairment by overlapping mechanisms. The purpose of this study was to test the hypothesis that alternate-day caloric restriction (ADCR) with overall energy balance would reduce insulin resistance and accumulation of visceral fat, in addition to improving cognitive functions, after 8 consecutive days in bed. Healthy, lean men (n = 20) were randomized to 1) 8 days of bed rest with three daily isoenergetic meals (control group, n = 10); and 2) 8 days of bed rest with 25% of total energy requirements every other day and 175% of total energy requirements every other day (ADCR group). Oral glucose tolerance testing, dual-energy X-ray absorptiometry (DXA) scans, magnetic resonance imaging of the abdomen and brain, {\.V}o2max, and tests for cognitive function were performed before and after bed rest. In addition, daily fasting blood samples and 24-h glucose profiles by continuous glucose monitoring system were assessed during the 8 days of bed rest period. Bed rest induced insulin resistance, visceral fat accumulation, and worsening of mood. No positive effects emerged from ADCR on these negative health outcomes. Compared with the control group, ADCR was associated with improved and steadier glycemic control on fasting days and higher glycemic fluctuation and indexes of insulin resistance on overeating days. In contrast to our hypothesis, the metabolic impairment induced by 8 days of bed rest was not counteracted by ADCR with overall energy balance.NEW & NOTEWORTHY: Alternate-day caloric restriction without overall energy reduction does not ameliorate the metabolic impairment induced in lean men by 8 days of bed rest.",

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AU - Lyngbæk, Mark Preben

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AU - Langkilde, Annika Reynberg

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ER -

The effect of alternate-day caloric restriction on the metabolic consequences of 8 days of bed rest in healthy lean men: a randomized trial

Abstract

Keywords

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