TY - JOUR
T1 - The effect of alternate-day caloric restriction on the metabolic consequences of 8 days of bed rest in healthy lean men
T2 - a randomized trial
AU - Harder-Lauridsen, Nina Majlund
AU - Nielsen, Signe Tellerup
AU - Mann, Sebastian Porsdam
AU - Lyngbæk, Mark Preben
AU - Benatti, Fabiana Braga
AU - Langkilde, Annika Reynberg
AU - Law, Ian
AU - Wedell-Neergaard, Anne-Sophie
AU - Thomsen, Carsten
AU - Møller, Kirsten
AU - Karstoft, Kristian
AU - Pedersen, Bente Klarlund
AU - Krogh-Madsen, Rikke
N1 - Copyright © 2017 the American Physiological Society.
PY - 2017/2
Y1 - 2017/2
N2 - Physical activity and alternate-day fasting/caloric restriction may both ameliorate aspects of the metabolic syndrome, such as insulin resistance, visceral fat mass accumulation, and cognitive impairment by overlapping mechanisms. The purpose of this study was to test the hypothesis that alternate-day caloric restriction (ADCR) with overall energy balance would reduce insulin resistance and accumulation of visceral fat, in addition to improving cognitive functions, after 8 consecutive days in bed. Healthy, lean men (n = 20) were randomized to 1) 8 days of bed rest with three daily isoenergetic meals (control group, n = 10); and 2) 8 days of bed rest with 25% of total energy requirements every other day and 175% of total energy requirements every other day (ADCR group). Oral glucose tolerance testing, dual-energy X-ray absorptiometry (DXA) scans, magnetic resonance imaging of the abdomen and brain, V̇o2max, and tests for cognitive function were performed before and after bed rest. In addition, daily fasting blood samples and 24-h glucose profiles by continuous glucose monitoring system were assessed during the 8 days of bed rest period. Bed rest induced insulin resistance, visceral fat accumulation, and worsening of mood. No positive effects emerged from ADCR on these negative health outcomes. Compared with the control group, ADCR was associated with improved and steadier glycemic control on fasting days and higher glycemic fluctuation and indexes of insulin resistance on overeating days. In contrast to our hypothesis, the metabolic impairment induced by 8 days of bed rest was not counteracted by ADCR with overall energy balance.NEW & NOTEWORTHY: Alternate-day caloric restriction without overall energy reduction does not ameliorate the metabolic impairment induced in lean men by 8 days of bed rest.
AB - Physical activity and alternate-day fasting/caloric restriction may both ameliorate aspects of the metabolic syndrome, such as insulin resistance, visceral fat mass accumulation, and cognitive impairment by overlapping mechanisms. The purpose of this study was to test the hypothesis that alternate-day caloric restriction (ADCR) with overall energy balance would reduce insulin resistance and accumulation of visceral fat, in addition to improving cognitive functions, after 8 consecutive days in bed. Healthy, lean men (n = 20) were randomized to 1) 8 days of bed rest with three daily isoenergetic meals (control group, n = 10); and 2) 8 days of bed rest with 25% of total energy requirements every other day and 175% of total energy requirements every other day (ADCR group). Oral glucose tolerance testing, dual-energy X-ray absorptiometry (DXA) scans, magnetic resonance imaging of the abdomen and brain, V̇o2max, and tests for cognitive function were performed before and after bed rest. In addition, daily fasting blood samples and 24-h glucose profiles by continuous glucose monitoring system were assessed during the 8 days of bed rest period. Bed rest induced insulin resistance, visceral fat accumulation, and worsening of mood. No positive effects emerged from ADCR on these negative health outcomes. Compared with the control group, ADCR was associated with improved and steadier glycemic control on fasting days and higher glycemic fluctuation and indexes of insulin resistance on overeating days. In contrast to our hypothesis, the metabolic impairment induced by 8 days of bed rest was not counteracted by ADCR with overall energy balance.NEW & NOTEWORTHY: Alternate-day caloric restriction without overall energy reduction does not ameliorate the metabolic impairment induced in lean men by 8 days of bed rest.
KW - Adult
KW - Affect/physiology
KW - Bed Rest/adverse effects
KW - Blood Glucose/metabolism
KW - Caloric Restriction/methods
KW - Cognition/physiology
KW - Energy Metabolism/physiology
KW - Exercise/physiology
KW - Fasting/physiology
KW - Glucose/metabolism
KW - Glucose Tolerance Test/methods
KW - Humans
KW - Insulin/metabolism
KW - Insulin Resistance/physiology
KW - Intra-Abdominal Fat/metabolism
KW - Male
KW - Metabolic Syndrome/metabolism
KW - Young Adult
U2 - 10.1152/japplphysiol.00846.2016
DO - 10.1152/japplphysiol.00846.2016
M3 - Journal article
C2 - 27881670
SN - 8750-7587
VL - 122
SP - 230
EP - 241
JO - Journal of Applied Physiology
JF - Journal of Applied Physiology
IS - 2
ER -