The Effect of acute exercise on lymphocyte subsets, natural killer cells, proliferative responses, and cytokines in hiv-seropositive persons

Henrik Ullum; Jan Palmø; Jens Halkjær-Kristensen; Marcus Diamant; Mads Klokker; Alexandra Kruuse; Arthur LaPerriere; Bente Klarlund Pedersen

The Effect of acute exercise on lymphocyte subsets, natural killer cells, proliferative responses, and cytokines in hiv-seropositive persons

Henrik Ullum, Jan Palmø, Jens Halkjær-Kristensen, Marcus Diamant, Mads Klokker, Alexandra Kruuse, Arthur LaPerriere, Bente Klarlund Pedersen^*

^*Corresponding author for this work

48 Citations (Scopus)

Abstract

Eight healthy men infected with human immunodeficiency virus, type 1 (HIV) and eight HIV seronegative age- and sex-matched controls exercised on a bicycle ergometer (75% of VO₂max, 1 h). The percentages of CD4 ⁺, CD4 ⁺ 45RA ⁺ , and CD4⁺45RO⁺ cells did not change, whereas the absolute number of CD4⁺ cells increased twofold during exercise and fell below prevalues 2 h after. The neutrophil count increase was more pronounced after exercise in the controls compared with in HIV-seropositive subjects. The percent CD16⁺ cells, and the natural killer (NK) and lymphokine activated killer (LAK) cell activity increased during exercise, but this increase was significantly less pronounced in the HIV-seropositive group. The results suggest that in response to physical stress, HIV-seropositive subjects have an impaired ability to mobilize neutrophils, NK and LAK cells to the blood. Furthermore, because the total number of CD4⁺ cells, but not the percentage of CD4⁺ cells, changed in response to exercise, this study further strengthens the idea that the percentage of CD4 ⁺ cells is preferable to the number of CD4 ⁺ cells in monitoring patients seropositive for HIV.

Original language	English
Journal	Journal of Acquired Immune Deficiency Syndromes
Volume	7
Issue number	11
Pages (from-to)	1122-1133
Number of pages	12
ISSN	1525-4135
Publication status	Published - 1 Jan 1994

Keywords

Blood mono
Cytokines
HIV seropositive
Interleukins
Lymphocytes
Lymphokine activated killer cells
Natural killer cells
nuclear cell subsets
Physical exercise
Proliferative responses

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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The Effect of acute exercise on lymphocyte subsets, natural killer cells, proliferative responses, and cytokines in hiv-seropositive persons. / Ullum, Henrik; Palmø, Jan; Halkjær-Kristensen, Jens et al.
In: Journal of Acquired Immune Deficiency Syndromes, Vol. 7, No. 11, 01.01.1994, p. 1122-1133.

Research output: Contribution to journal › Journal article › Research › peer-review

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abstract = "Eight healthy men infected with human immunodeficiency virus, type 1 (HIV) and eight HIV seronegative age- and sex-matched controls exercised on a bicycle ergometer (75% of VO2max, 1 h). The percentages of CD4 +, CD4 + 45RA + , and CD4+45RO+ cells did not change, whereas the absolute number of CD4+ cells increased twofold during exercise and fell below prevalues 2 h after. The neutrophil count increase was more pronounced after exercise in the controls compared with in HIV-seropositive subjects. The percent CD16+ cells, and the natural killer (NK) and lymphokine activated killer (LAK) cell activity increased during exercise, but this increase was significantly less pronounced in the HIV-seropositive group. The results suggest that in response to physical stress, HIV-seropositive subjects have an impaired ability to mobilize neutrophils, NK and LAK cells to the blood. Furthermore, because the total number of CD4+ cells, but not the percentage of CD4+ cells, changed in response to exercise, this study further strengthens the idea that the percentage of CD4 + cells is preferable to the number of CD4 + cells in monitoring patients seropositive for HIV.",

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AU - Palmø, Jan

AU - Halkjær-Kristensen, Jens

AU - Diamant, Marcus

AU - Klokker, Mads

AU - Kruuse, Alexandra

AU - LaPerriere, Arthur

AU - Pedersen, Bente Klarlund

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N2 - Eight healthy men infected with human immunodeficiency virus, type 1 (HIV) and eight HIV seronegative age- and sex-matched controls exercised on a bicycle ergometer (75% of VO2max, 1 h). The percentages of CD4 +, CD4 + 45RA + , and CD4+45RO+ cells did not change, whereas the absolute number of CD4+ cells increased twofold during exercise and fell below prevalues 2 h after. The neutrophil count increase was more pronounced after exercise in the controls compared with in HIV-seropositive subjects. The percent CD16+ cells, and the natural killer (NK) and lymphokine activated killer (LAK) cell activity increased during exercise, but this increase was significantly less pronounced in the HIV-seropositive group. The results suggest that in response to physical stress, HIV-seropositive subjects have an impaired ability to mobilize neutrophils, NK and LAK cells to the blood. Furthermore, because the total number of CD4+ cells, but not the percentage of CD4+ cells, changed in response to exercise, this study further strengthens the idea that the percentage of CD4 + cells is preferable to the number of CD4 + cells in monitoring patients seropositive for HIV.

AB - Eight healthy men infected with human immunodeficiency virus, type 1 (HIV) and eight HIV seronegative age- and sex-matched controls exercised on a bicycle ergometer (75% of VO2max, 1 h). The percentages of CD4 +, CD4 + 45RA + , and CD4+45RO+ cells did not change, whereas the absolute number of CD4+ cells increased twofold during exercise and fell below prevalues 2 h after. The neutrophil count increase was more pronounced after exercise in the controls compared with in HIV-seropositive subjects. The percent CD16+ cells, and the natural killer (NK) and lymphokine activated killer (LAK) cell activity increased during exercise, but this increase was significantly less pronounced in the HIV-seropositive group. The results suggest that in response to physical stress, HIV-seropositive subjects have an impaired ability to mobilize neutrophils, NK and LAK cells to the blood. Furthermore, because the total number of CD4+ cells, but not the percentage of CD4+ cells, changed in response to exercise, this study further strengthens the idea that the percentage of CD4 + cells is preferable to the number of CD4 + cells in monitoring patients seropositive for HIV.

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KW - Cytokines

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KW - Lymphocytes

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KW - nuclear cell subsets

KW - Physical exercise

KW - Proliferative responses

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The Effect of acute exercise on lymphocyte subsets, natural killer cells, proliferative responses, and cytokines in hiv-seropositive persons

Abstract

Keywords

UN SDGs

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