The Effect of acute exercise on lymphocyte subsets, natural killer cells, proliferative responses, and cytokines in hiv-seropositive persons

Henrik Ullum; Jan Palmø; Jens Halkjær-Kristensen; Marcus Diamant; Mads Klokker; Alexandra Kruuse; Arthur LaPerriere; Bente Klarlund Pedersen

The Effect of acute exercise on lymphocyte subsets, natural killer cells, proliferative responses, and cytokines in hiv-seropositive persons

Henrik Ullum, Jan Palmø, Jens Halkjær-Kristensen, Marcus Diamant, Mads Klokker, Alexandra Kruuse, Arthur LaPerriere, Bente Klarlund Pedersen^*

^*Corresponding author af dette arbejde

48 Citationer (Scopus)

Abstract

Eight healthy men infected with human immunodeficiency virus, type 1 (HIV) and eight HIV seronegative age- and sex-matched controls exercised on a bicycle ergometer (75% of VO₂max, 1 h). The percentages of CD4 ⁺, CD4 ⁺ 45RA ⁺ , and CD4⁺45RO⁺ cells did not change, whereas the absolute number of CD4⁺ cells increased twofold during exercise and fell below prevalues 2 h after. The neutrophil count increase was more pronounced after exercise in the controls compared with in HIV-seropositive subjects. The percent CD16⁺ cells, and the natural killer (NK) and lymphokine activated killer (LAK) cell activity increased during exercise, but this increase was significantly less pronounced in the HIV-seropositive group. The results suggest that in response to physical stress, HIV-seropositive subjects have an impaired ability to mobilize neutrophils, NK and LAK cells to the blood. Furthermore, because the total number of CD4⁺ cells, but not the percentage of CD4⁺ cells, changed in response to exercise, this study further strengthens the idea that the percentage of CD4 ⁺ cells is preferable to the number of CD4 ⁺ cells in monitoring patients seropositive for HIV.

Originalsprog	Engelsk
Tidsskrift	Journal of Acquired Immune Deficiency Syndromes
Vol/bind	7
Udgave nummer	11
Sider (fra-til)	1122-1133
Antal sider	12
ISSN	1525-4135
Status	Udgivet - 1 jan. 1994

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The Effect of acute exercise on lymphocyte subsets, natural killer cells, proliferative responses, and cytokines in hiv-seropositive persons. / Ullum, Henrik; Palmø, Jan; Halkjær-Kristensen, Jens et al.
I: Journal of Acquired Immune Deficiency Syndromes, Bind 7, Nr. 11, 01.01.1994, s. 1122-1133.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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title = "The Effect of acute exercise on lymphocyte subsets, natural killer cells, proliferative responses, and cytokines in hiv-seropositive persons",

abstract = "Eight healthy men infected with human immunodeficiency virus, type 1 (HIV) and eight HIV seronegative age- and sex-matched controls exercised on a bicycle ergometer (75% of VO2max, 1 h). The percentages of CD4 +, CD4 + 45RA + , and CD4+45RO+ cells did not change, whereas the absolute number of CD4+ cells increased twofold during exercise and fell below prevalues 2 h after. The neutrophil count increase was more pronounced after exercise in the controls compared with in HIV-seropositive subjects. The percent CD16+ cells, and the natural killer (NK) and lymphokine activated killer (LAK) cell activity increased during exercise, but this increase was significantly less pronounced in the HIV-seropositive group. The results suggest that in response to physical stress, HIV-seropositive subjects have an impaired ability to mobilize neutrophils, NK and LAK cells to the blood. Furthermore, because the total number of CD4+ cells, but not the percentage of CD4+ cells, changed in response to exercise, this study further strengthens the idea that the percentage of CD4 + cells is preferable to the number of CD4 + cells in monitoring patients seropositive for HIV.",

keywords = "Blood mono, Cytokines, HIV seropositive, Interleukins, Lymphocytes, Lymphokine activated killer cells, Natural killer cells, nuclear cell subsets, Physical exercise, Proliferative responses",

author = "Henrik Ullum and Jan Palm{\o} and Jens Halkj{\ae}r-Kristensen and Marcus Diamant and Mads Klokker and Alexandra Kruuse and Arthur LaPerriere and Pedersen, {Bente Klarlund}",

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T1 - The Effect of acute exercise on lymphocyte subsets, natural killer cells, proliferative responses, and cytokines in hiv-seropositive persons

AU - Ullum, Henrik

AU - Palmø, Jan

AU - Halkjær-Kristensen, Jens

AU - Diamant, Marcus

AU - Klokker, Mads

AU - Kruuse, Alexandra

AU - LaPerriere, Arthur

AU - Pedersen, Bente Klarlund

PY - 1994/1/1

Y1 - 1994/1/1

N2 - Eight healthy men infected with human immunodeficiency virus, type 1 (HIV) and eight HIV seronegative age- and sex-matched controls exercised on a bicycle ergometer (75% of VO2max, 1 h). The percentages of CD4 +, CD4 + 45RA + , and CD4+45RO+ cells did not change, whereas the absolute number of CD4+ cells increased twofold during exercise and fell below prevalues 2 h after. The neutrophil count increase was more pronounced after exercise in the controls compared with in HIV-seropositive subjects. The percent CD16+ cells, and the natural killer (NK) and lymphokine activated killer (LAK) cell activity increased during exercise, but this increase was significantly less pronounced in the HIV-seropositive group. The results suggest that in response to physical stress, HIV-seropositive subjects have an impaired ability to mobilize neutrophils, NK and LAK cells to the blood. Furthermore, because the total number of CD4+ cells, but not the percentage of CD4+ cells, changed in response to exercise, this study further strengthens the idea that the percentage of CD4 + cells is preferable to the number of CD4 + cells in monitoring patients seropositive for HIV.

AB - Eight healthy men infected with human immunodeficiency virus, type 1 (HIV) and eight HIV seronegative age- and sex-matched controls exercised on a bicycle ergometer (75% of VO2max, 1 h). The percentages of CD4 +, CD4 + 45RA + , and CD4+45RO+ cells did not change, whereas the absolute number of CD4+ cells increased twofold during exercise and fell below prevalues 2 h after. The neutrophil count increase was more pronounced after exercise in the controls compared with in HIV-seropositive subjects. The percent CD16+ cells, and the natural killer (NK) and lymphokine activated killer (LAK) cell activity increased during exercise, but this increase was significantly less pronounced in the HIV-seropositive group. The results suggest that in response to physical stress, HIV-seropositive subjects have an impaired ability to mobilize neutrophils, NK and LAK cells to the blood. Furthermore, because the total number of CD4+ cells, but not the percentage of CD4+ cells, changed in response to exercise, this study further strengthens the idea that the percentage of CD4 + cells is preferable to the number of CD4 + cells in monitoring patients seropositive for HIV.

KW - Blood mono

KW - Cytokines

KW - HIV seropositive

KW - Interleukins

KW - Lymphocytes

KW - Lymphokine activated killer cells

KW - Natural killer cells

KW - nuclear cell subsets

KW - Physical exercise

KW - Proliferative responses

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JF - Journal of Acquired Immune Deficiency Syndromes

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The Effect of acute exercise on lymphocyte subsets, natural killer cells, proliferative responses, and cytokines in hiv-seropositive persons

Abstract

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