The diagnostic efficiency of biomarkers in sporadic Creutzfeldt-Jakob disease compared to Alzheimer's disease

J.M. Bahl; N.H. Heegaard; G. Falkenhorst; H. Laursen; H. Hogenhaven; K. Molbak; C. Jespersgaard; L. Hougs; G. Waldemar; P. Johannsen; M. Christiansen

doi:http://dx.doi.org/10.1016/j.neurobiolaging.2008.01.013

The diagnostic efficiency of biomarkers in sporadic Creutzfeldt-Jakob disease compared to Alzheimer's disease

J.M. Bahl, N.H. Heegaard, G. Falkenhorst, H. Laursen, H. Hogenhaven, K. Molbak, C. Jespersgaard, L. Hougs, G. Waldemar, P. Johannsen, M. Christiansen

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Abstract

Laboratory markers have a prominent place among the diagnostic criteria for sporadic Creutzfeldt-Jakob disease (sCJD). Here we investigate the capability of protein 14-3-3, total-tau (t-tau), threonin-181-phosphorylated tau (p-tau), and neuron-specific enolase (NSE) in cerebrospinal fluid (CSF) together with the prion protein gene genotype to discriminate patients with sCJD (n=21) from neurological controls (n=164) and Alzheimer's disease (AD) patients (n=49). Low p-tau/t-tau ratio was the best single marker for sCJD with 90% specificity against neurological controls at 86% sensitivity whilst NSE was the least accurate with 79% sensitivity at 90% specificity. Many of the sCJD patients had extremely elevated t-tau values but normal values of the AD-marker p-tau. Protein 14-3-3 was very sensitive (95%) although the specificity was relatively low (75%). A combination of elevated t-tau concentration with the presence of 14-3-3 protein in CSF gave the best test specificity of 96% at 84% sensitivity. We conclude that the combination of more than one CSF marker for neurodegeneration can improve the diagnostic test accuracy for sCJD against neurological controls including patients with other dementias
Udgivelsesdato: 2009/11

Original language	English
Journal	Neurobiology of Aging
Volume	30
Issue number	11
Pages (from-to)	1834-1841
Number of pages	8
ISSN	0197-4580
DOIs	https://doi.org/10.1016/j.neurobiolaging.2008.01.013
Publication status	Published - 2009

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http://dx.doi.org/10.1016/j.neurobiolaging.2008.01.013

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Bahl, J. M., Heegaard, N. H., Falkenhorst, G., Laursen, H., Hogenhaven, H., Molbak, K., Jespersgaard, C., Hougs, L., Waldemar, G., Johannsen, P., & Christiansen, M. (2009). The diagnostic efficiency of biomarkers in sporadic Creutzfeldt-Jakob disease compared to Alzheimer's disease. Neurobiology of Aging, 30(11), 1834-1841. https://doi.org/10.1016/j.neurobiolaging.2008.01.013

Bahl, JM, Heegaard, NH, Falkenhorst, G, Laursen, H, Hogenhaven, H, Molbak, K, Jespersgaard, C, Hougs, L, Waldemar, G, Johannsen, P & Christiansen, M 2009, 'The diagnostic efficiency of biomarkers in sporadic Creutzfeldt-Jakob disease compared to Alzheimer's disease', Neurobiology of Aging, vol. 30, no. 11, pp. 1834-1841. https://doi.org/10.1016/j.neurobiolaging.2008.01.013

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title = "The diagnostic efficiency of biomarkers in sporadic Creutzfeldt-Jakob disease compared to Alzheimer's disease",

abstract = "Laboratory markers have a prominent place among the diagnostic criteria for sporadic Creutzfeldt-Jakob disease (sCJD). Here we investigate the capability of protein 14-3-3, total-tau (t-tau), threonin-181-phosphorylated tau (p-tau), and neuron-specific enolase (NSE) in cerebrospinal fluid (CSF) together with the prion protein gene genotype to discriminate patients with sCJD (n=21) from neurological controls (n=164) and Alzheimer's disease (AD) patients (n=49). Low p-tau/t-tau ratio was the best single marker for sCJD with 90% specificity against neurological controls at 86% sensitivity whilst NSE was the least accurate with 79% sensitivity at 90% specificity. Many of the sCJD patients had extremely elevated t-tau values but normal values of the AD-marker p-tau. Protein 14-3-3 was very sensitive (95%) although the specificity was relatively low (75%). A combination of elevated t-tau concentration with the presence of 14-3-3 protein in CSF gave the best test specificity of 96% at 84% sensitivity. We conclude that the combination of more than one CSF marker for neurodegeneration can improve the diagnostic test accuracy for sCJD against neurological controls including patients with other dementias Udgivelsesdato: 2009/11",

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T1 - The diagnostic efficiency of biomarkers in sporadic Creutzfeldt-Jakob disease compared to Alzheimer's disease

AU - Bahl, J.M.

AU - Heegaard, N.H.

AU - Falkenhorst, G.

AU - Laursen, H.

AU - Hogenhaven, H.

AU - Molbak, K.

AU - Jespersgaard, C.

AU - Hougs, L.

AU - Waldemar, G.

AU - Johannsen, P.

AU - Christiansen, M.

PY - 2009

Y1 - 2009

N2 - Laboratory markers have a prominent place among the diagnostic criteria for sporadic Creutzfeldt-Jakob disease (sCJD). Here we investigate the capability of protein 14-3-3, total-tau (t-tau), threonin-181-phosphorylated tau (p-tau), and neuron-specific enolase (NSE) in cerebrospinal fluid (CSF) together with the prion protein gene genotype to discriminate patients with sCJD (n=21) from neurological controls (n=164) and Alzheimer's disease (AD) patients (n=49). Low p-tau/t-tau ratio was the best single marker for sCJD with 90% specificity against neurological controls at 86% sensitivity whilst NSE was the least accurate with 79% sensitivity at 90% specificity. Many of the sCJD patients had extremely elevated t-tau values but normal values of the AD-marker p-tau. Protein 14-3-3 was very sensitive (95%) although the specificity was relatively low (75%). A combination of elevated t-tau concentration with the presence of 14-3-3 protein in CSF gave the best test specificity of 96% at 84% sensitivity. We conclude that the combination of more than one CSF marker for neurodegeneration can improve the diagnostic test accuracy for sCJD against neurological controls including patients with other dementias Udgivelsesdato: 2009/11

AB - Laboratory markers have a prominent place among the diagnostic criteria for sporadic Creutzfeldt-Jakob disease (sCJD). Here we investigate the capability of protein 14-3-3, total-tau (t-tau), threonin-181-phosphorylated tau (p-tau), and neuron-specific enolase (NSE) in cerebrospinal fluid (CSF) together with the prion protein gene genotype to discriminate patients with sCJD (n=21) from neurological controls (n=164) and Alzheimer's disease (AD) patients (n=49). Low p-tau/t-tau ratio was the best single marker for sCJD with 90% specificity against neurological controls at 86% sensitivity whilst NSE was the least accurate with 79% sensitivity at 90% specificity. Many of the sCJD patients had extremely elevated t-tau values but normal values of the AD-marker p-tau. Protein 14-3-3 was very sensitive (95%) although the specificity was relatively low (75%). A combination of elevated t-tau concentration with the presence of 14-3-3 protein in CSF gave the best test specificity of 96% at 84% sensitivity. We conclude that the combination of more than one CSF marker for neurodegeneration can improve the diagnostic test accuracy for sCJD against neurological controls including patients with other dementias Udgivelsesdato: 2009/11

U2 - http://dx.doi.org/10.1016/j.neurobiolaging.2008.01.013

DO - http://dx.doi.org/10.1016/j.neurobiolaging.2008.01.013

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