The diagnostic efficiency of biomarkers in sporadic Creutzfeldt-Jakob disease compared to Alzheimer's disease

J.M. Bahl; N.H. Heegaard; G. Falkenhorst; H. Laursen; H. Hogenhaven; K. Molbak; C. Jespersgaard; L. Hougs; G. Waldemar; P. Johannsen; M. Christiansen

doi:http://dx.doi.org/10.1016/j.neurobiolaging.2008.01.013

The diagnostic efficiency of biomarkers in sporadic Creutzfeldt-Jakob disease compared to Alzheimer's disease

J.M. Bahl, N.H. Heegaard, G. Falkenhorst, H. Laursen, H. Hogenhaven, K. Molbak, C. Jespersgaard, L. Hougs, G. Waldemar, P. Johannsen, M. Christiansen

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40 Citationer (Scopus)

Abstract

Laboratory markers have a prominent place among the diagnostic criteria for sporadic Creutzfeldt-Jakob disease (sCJD). Here we investigate the capability of protein 14-3-3, total-tau (t-tau), threonin-181-phosphorylated tau (p-tau), and neuron-specific enolase (NSE) in cerebrospinal fluid (CSF) together with the prion protein gene genotype to discriminate patients with sCJD (n=21) from neurological controls (n=164) and Alzheimer's disease (AD) patients (n=49). Low p-tau/t-tau ratio was the best single marker for sCJD with 90% specificity against neurological controls at 86% sensitivity whilst NSE was the least accurate with 79% sensitivity at 90% specificity. Many of the sCJD patients had extremely elevated t-tau values but normal values of the AD-marker p-tau. Protein 14-3-3 was very sensitive (95%) although the specificity was relatively low (75%). A combination of elevated t-tau concentration with the presence of 14-3-3 protein in CSF gave the best test specificity of 96% at 84% sensitivity. We conclude that the combination of more than one CSF marker for neurodegeneration can improve the diagnostic test accuracy for sCJD against neurological controls including patients with other dementias
Udgivelsesdato: 2009/11

Originalsprog	Engelsk
Tidsskrift	Neurobiology of Aging
Vol/bind	30
Udgave nummer	11
Sider (fra-til)	1834-1841
Antal sider	8
ISSN	0197-4580
DOI	https://doi.org/10.1016/j.neurobiolaging.2008.01.013
Status	Udgivet - 2009

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http://dx.doi.org/10.1016/j.neurobiolaging.2008.01.013

Citationsformater

Bahl, J. M., Heegaard, N. H., Falkenhorst, G., Laursen, H., Hogenhaven, H., Molbak, K., Jespersgaard, C., Hougs, L., Waldemar, G., Johannsen, P., & Christiansen, M. (2009). The diagnostic efficiency of biomarkers in sporadic Creutzfeldt-Jakob disease compared to Alzheimer's disease. Neurobiology of Aging, 30(11), 1834-1841. https://doi.org/10.1016/j.neurobiolaging.2008.01.013

Bahl, JM, Heegaard, NH, Falkenhorst, G, Laursen, H, Hogenhaven, H, Molbak, K, Jespersgaard, C, Hougs, L, Waldemar, G, Johannsen, P & Christiansen, M 2009, 'The diagnostic efficiency of biomarkers in sporadic Creutzfeldt-Jakob disease compared to Alzheimer's disease', Neurobiology of Aging, bind 30, nr. 11, s. 1834-1841. https://doi.org/10.1016/j.neurobiolaging.2008.01.013

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title = "The diagnostic efficiency of biomarkers in sporadic Creutzfeldt-Jakob disease compared to Alzheimer's disease",

abstract = "Laboratory markers have a prominent place among the diagnostic criteria for sporadic Creutzfeldt-Jakob disease (sCJD). Here we investigate the capability of protein 14-3-3, total-tau (t-tau), threonin-181-phosphorylated tau (p-tau), and neuron-specific enolase (NSE) in cerebrospinal fluid (CSF) together with the prion protein gene genotype to discriminate patients with sCJD (n=21) from neurological controls (n=164) and Alzheimer's disease (AD) patients (n=49). Low p-tau/t-tau ratio was the best single marker for sCJD with 90% specificity against neurological controls at 86% sensitivity whilst NSE was the least accurate with 79% sensitivity at 90% specificity. Many of the sCJD patients had extremely elevated t-tau values but normal values of the AD-marker p-tau. Protein 14-3-3 was very sensitive (95%) although the specificity was relatively low (75%). A combination of elevated t-tau concentration with the presence of 14-3-3 protein in CSF gave the best test specificity of 96% at 84% sensitivity. We conclude that the combination of more than one CSF marker for neurodegeneration can improve the diagnostic test accuracy for sCJD against neurological controls including patients with other dementias Udgivelsesdato: 2009/11",

author = "J.M. Bahl and N.H. Heegaard and G. Falkenhorst and H. Laursen and H. Hogenhaven and K. Molbak and C. Jespersgaard and L. Hougs and G. Waldemar and P. Johannsen and M. Christiansen",

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T1 - The diagnostic efficiency of biomarkers in sporadic Creutzfeldt-Jakob disease compared to Alzheimer's disease

AU - Bahl, J.M.

AU - Heegaard, N.H.

AU - Falkenhorst, G.

AU - Laursen, H.

AU - Hogenhaven, H.

AU - Molbak, K.

AU - Jespersgaard, C.

AU - Hougs, L.

AU - Waldemar, G.

AU - Johannsen, P.

AU - Christiansen, M.

PY - 2009

Y1 - 2009

N2 - Laboratory markers have a prominent place among the diagnostic criteria for sporadic Creutzfeldt-Jakob disease (sCJD). Here we investigate the capability of protein 14-3-3, total-tau (t-tau), threonin-181-phosphorylated tau (p-tau), and neuron-specific enolase (NSE) in cerebrospinal fluid (CSF) together with the prion protein gene genotype to discriminate patients with sCJD (n=21) from neurological controls (n=164) and Alzheimer's disease (AD) patients (n=49). Low p-tau/t-tau ratio was the best single marker for sCJD with 90% specificity against neurological controls at 86% sensitivity whilst NSE was the least accurate with 79% sensitivity at 90% specificity. Many of the sCJD patients had extremely elevated t-tau values but normal values of the AD-marker p-tau. Protein 14-3-3 was very sensitive (95%) although the specificity was relatively low (75%). A combination of elevated t-tau concentration with the presence of 14-3-3 protein in CSF gave the best test specificity of 96% at 84% sensitivity. We conclude that the combination of more than one CSF marker for neurodegeneration can improve the diagnostic test accuracy for sCJD against neurological controls including patients with other dementias Udgivelsesdato: 2009/11

AB - Laboratory markers have a prominent place among the diagnostic criteria for sporadic Creutzfeldt-Jakob disease (sCJD). Here we investigate the capability of protein 14-3-3, total-tau (t-tau), threonin-181-phosphorylated tau (p-tau), and neuron-specific enolase (NSE) in cerebrospinal fluid (CSF) together with the prion protein gene genotype to discriminate patients with sCJD (n=21) from neurological controls (n=164) and Alzheimer's disease (AD) patients (n=49). Low p-tau/t-tau ratio was the best single marker for sCJD with 90% specificity against neurological controls at 86% sensitivity whilst NSE was the least accurate with 79% sensitivity at 90% specificity. Many of the sCJD patients had extremely elevated t-tau values but normal values of the AD-marker p-tau. Protein 14-3-3 was very sensitive (95%) although the specificity was relatively low (75%). A combination of elevated t-tau concentration with the presence of 14-3-3 protein in CSF gave the best test specificity of 96% at 84% sensitivity. We conclude that the combination of more than one CSF marker for neurodegeneration can improve the diagnostic test accuracy for sCJD against neurological controls including patients with other dementias Udgivelsesdato: 2009/11

U2 - http://dx.doi.org/10.1016/j.neurobiolaging.2008.01.013

DO - http://dx.doi.org/10.1016/j.neurobiolaging.2008.01.013

M3 - Journal article

SN - 0197-4580

VL - 30

SP - 1834

EP - 1841

JO - Neurobiology of Aging

JF - Neurobiology of Aging

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