The current role of MRI in differentiating multiple sclerosis from its imaging mimics

Ruth Geraldes; Olga Ciccarelli; Frederik Barkhof; Nicola De Stefano; Christian Enzinger; Massimo Filippi; Monika Hofer; Friedemann Paul; Paolo Preziosa; Alex Rovira; Gabriele C DeLuca; Ludwig Kappos; Tarek Yousry; Franz Fazekas; Jette Frederiksen; Claudio Gasperini; Jaume Sastre-Garriga; Nikos Evangelou; Jacqueline Palace; MAGNIMS study group

doi:10.1038/nrneurol.2018.14

The current role of MRI in differentiating multiple sclerosis from its imaging mimics

Ruth Geraldes, Olga Ciccarelli, Frederik Barkhof, Nicola De Stefano, Christian Enzinger, Massimo Filippi, Monika Hofer, Friedemann Paul, Paolo Preziosa, Alex Rovira, Gabriele C DeLuca, Ludwig Kappos, Tarek Yousry, Franz Fazekas, Jette Frederiksen, Claudio Gasperini, Jaume Sastre-Garriga, Nikos Evangelou, Jacqueline Palace, MAGNIMS study group

Department of Clinical Medicine

77 Citations (Scopus)

Abstract

MRI red flags proposed over a decade ago by the European Magnetic Resonance Network in MS (MAGNIMS) have guided clinicians in the diagnosis of multiple sclerosis (MS). However, the past 10 years have seen increased recognition that vascular disease can coexist and possibly interact with MS, improvements in the reliability of ways to differentiate MS from novel antibody-mediated CNS disorders (such as anti-aquaporin-4 antibody and myelin-oligodendrocyte glycoprotein antibody-associated diseases) and advances in MRI techniques. In this Review, MAGNIMS updates the imaging features that differentiate the most common mimics of MS, particularly age-related cerebrovascular disease and neuromyelitis optica, from MS itself. We also provide a pragmatic summary of the clinically useful MRI features that distinguish MS from its mimics and discuss the future of nonconventional techniques that have identified promising disease-specific features.

Original language	English
Journal	Nature Reviews. Neurology
Volume	14
Issue number	4
Pages (from-to)	199-213
ISSN	1759-4758
DOIs	https://doi.org/10.1038/nrneurol.2018.14
Publication status	Published - 1 Apr 2018

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Geraldes, R., Ciccarelli, O., Barkhof, F., De Stefano, N., Enzinger, C., Filippi, M., Hofer, M., Paul, F., Preziosa, P., Rovira, A., DeLuca, G. C., Kappos, L., Yousry, T., Fazekas, F., Frederiksen, J., Gasperini, C., Sastre-Garriga, J., Evangelou, N., Palace, J., & MAGNIMS study group (2018). The current role of MRI in differentiating multiple sclerosis from its imaging mimics. Nature Reviews. Neurology, 14(4), 199-213. https://doi.org/10.1038/nrneurol.2018.14

Geraldes, R, Ciccarelli, O, Barkhof, F, De Stefano, N, Enzinger, C, Filippi, M, Hofer, M, Paul, F, Preziosa, P, Rovira, A, DeLuca, GC, Kappos, L, Yousry, T, Fazekas, F, Frederiksen, J, Gasperini, C, Sastre-Garriga, J, Evangelou, N, Palace, J & MAGNIMS study group 2018, 'The current role of MRI in differentiating multiple sclerosis from its imaging mimics', Nature Reviews. Neurology, vol. 14, no. 4, pp. 199-213. https://doi.org/10.1038/nrneurol.2018.14

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abstract = "MRI red flags proposed over a decade ago by the European Magnetic Resonance Network in MS (MAGNIMS) have guided clinicians in the diagnosis of multiple sclerosis (MS). However, the past 10 years have seen increased recognition that vascular disease can coexist and possibly interact with MS, improvements in the reliability of ways to differentiate MS from novel antibody-mediated CNS disorders (such as anti-aquaporin-4 antibody and myelin-oligodendrocyte glycoprotein antibody-associated diseases) and advances in MRI techniques. In this Review, MAGNIMS updates the imaging features that differentiate the most common mimics of MS, particularly age-related cerebrovascular disease and neuromyelitis optica, from MS itself. We also provide a pragmatic summary of the clinically useful MRI features that distinguish MS from its mimics and discuss the future of nonconventional techniques that have identified promising disease-specific features.",

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The current role of MRI in differentiating multiple sclerosis from its imaging mimics

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