The Capsid Domain of Arc Changes Its Oligomerization Propensity through Direct Interaction with the NMDA Receptor

Lau Dalby Nielsen; Christian Parsbæk Pedersen; Simon Erlendsson; Kaare Teilum

doi:10.1016/j.str.2019.04.001

The Capsid Domain of Arc Changes Its Oligomerization Propensity through Direct Interaction with the NMDA Receptor

Lau Dalby Nielsen, Christian Parsbæk Pedersen, Simon Erlendsson, Kaare Teilum

Biomolecular Sciences

9 Citations (Scopus)

Abstract

Arc is a domesticated viral protein expressed in neurons and regulates processes underlying cognition and memory consolidation. Here, Nielsen et al. characterize the structure and dynamics of the capsid homology domain of Arc, and demonstrate that Arc interacts directly with several neuroreceptors and that these interactions interfere with domain oligomerization.

Original language	English
Journal	Structure
Volume	27
Issue number	7
Pages (from-to)	1071-1081, e1-e5
ISSN	0969-2126
DOIs	https://doi.org/10.1016/j.str.2019.04.001
Publication status	Published - 2 Jul 2019

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http://www.cell.com/article/S0969212619301236/pdf

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title = "The Capsid Domain of Arc Changes Its Oligomerization Propensity through Direct Interaction with the NMDA Receptor",

abstract = "Arc is a domesticated viral protein expressed in neurons and regulates processes underlying cognition and memory consolidation. Here, Nielsen et al. characterize the structure and dynamics of the capsid homology domain of Arc, and demonstrate that Arc interacts directly with several neuroreceptors and that these interactions interfere with domain oligomerization.",

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AU - Pedersen, Christian Parsbæk

AU - Erlendsson, Simon

AU - Teilum, Kaare

PY - 2019/7/2

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N2 - Arc is a domesticated viral protein expressed in neurons and regulates processes underlying cognition and memory consolidation. Here, Nielsen et al. characterize the structure and dynamics of the capsid homology domain of Arc, and demonstrate that Arc interacts directly with several neuroreceptors and that these interactions interfere with domain oligomerization.

AB - Arc is a domesticated viral protein expressed in neurons and regulates processes underlying cognition and memory consolidation. Here, Nielsen et al. characterize the structure and dynamics of the capsid homology domain of Arc, and demonstrate that Arc interacts directly with several neuroreceptors and that these interactions interfere with domain oligomerization.

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DO - 10.1016/j.str.2019.04.001

M3 - Journal article

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SN - 0969-2126

VL - 27

SP - 1071-1081, e1-e5

JO - Structure

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IS - 7

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The Capsid Domain of Arc Changes Its Oligomerization Propensity through Direct Interaction with the NMDA Receptor

Abstract

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