The Capsid Domain of Arc Changes Its Oligomerization Propensity through Direct Interaction with the NMDA Receptor

Lau Dalby Nielsen; Christian Parsbæk Pedersen; Simon Erlendsson; Kaare Teilum

doi:10.1016/j.str.2019.04.001

The Capsid Domain of Arc Changes Its Oligomerization Propensity through Direct Interaction with the NMDA Receptor

Lau Dalby Nielsen, Christian Parsbæk Pedersen, Simon Erlendsson, Kaare Teilum

Biomolecular Sciences

9 Citationer (Scopus)

Abstract

Arc is a domesticated viral protein expressed in neurons and regulates processes underlying cognition and memory consolidation. Here, Nielsen et al. characterize the structure and dynamics of the capsid homology domain of Arc, and demonstrate that Arc interacts directly with several neuroreceptors and that these interactions interfere with domain oligomerization.

Originalsprog	Engelsk
Tidsskrift	Structure
Vol/bind	27
Udgave nummer	7
Sider (fra-til)	1071-1081, e1-e5
ISSN	0969-2126
DOI	https://doi.org/10.1016/j.str.2019.04.001
Status	Udgivet - 2 jul. 2019

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10.1016/j.str.2019.04.001

http://www.cell.com/article/S0969212619301236/pdf

Citationsformater

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abstract = "Arc is a domesticated viral protein expressed in neurons and regulates processes underlying cognition and memory consolidation. Here, Nielsen et al. characterize the structure and dynamics of the capsid homology domain of Arc, and demonstrate that Arc interacts directly with several neuroreceptors and that these interactions interfere with domain oligomerization.",

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AU - Erlendsson, Simon

AU - Teilum, Kaare

PY - 2019/7/2

Y1 - 2019/7/2

N2 - Arc is a domesticated viral protein expressed in neurons and regulates processes underlying cognition and memory consolidation. Here, Nielsen et al. characterize the structure and dynamics of the capsid homology domain of Arc, and demonstrate that Arc interacts directly with several neuroreceptors and that these interactions interfere with domain oligomerization.

AB - Arc is a domesticated viral protein expressed in neurons and regulates processes underlying cognition and memory consolidation. Here, Nielsen et al. characterize the structure and dynamics of the capsid homology domain of Arc, and demonstrate that Arc interacts directly with several neuroreceptors and that these interactions interfere with domain oligomerization.

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DO - 10.1016/j.str.2019.04.001

M3 - Journal article

C2 - 31080121

SN - 0969-2126

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SP - 1071-1081, e1-e5

JO - Structure

JF - Structure

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ER -

The Capsid Domain of Arc Changes Its Oligomerization Propensity through Direct Interaction with the NMDA Receptor

Abstract

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