The association of IgA deficiency on infection rate, self-perceived health, and levels of C-reactive protein in healthy blood donors

Sabina Chaudhary Hauge; Charlotte Kæstel Jensen; Leif Kofoed Nielsen; Ole B. Pedersen; Erik Sørensen; Lise Wegner Thørner; Henrik Hjalgrim; Christian Erikstrup; Kaspar René Nielsen; Kathrine Agergård Kaspersen; Maria Didriksen; Morten Dziegiel; Henrik Ullum

doi:10.1111/apm.12807

The association of IgA deficiency on infection rate, self-perceived health, and levels of C-reactive protein in healthy blood donors

Sabina Chaudhary Hauge, Charlotte Kæstel Jensen, Leif Kofoed Nielsen, Ole B. Pedersen, Erik Sørensen, Lise Wegner Thørner, Henrik Hjalgrim, Christian Erikstrup, Kaspar René Nielsen, Kathrine Agergård Kaspersen, Maria Didriksen, Morten Dziegiel, Henrik Ullum^*

^*Corresponding author for this work

Department of Clinical Medicine

2 Citations (Scopus)

Abstract

The clinical importance of immunoglobulin A (IgA) deficiency in otherwise healthy individuals is not well described. We aimed to investigate the self-reported mental and physical health and the risk of infection in IgA-deficient blood donors compared to healthy control blood donors. Infectious events, recorded in public health registries either as prescriptions filled of any antimicrobial medicine or as hospital infections, were compared between 177 IgA-deficient blood donors and 1770 control blood donors. A subset of the IgA-deficient donors were further characterized by self-reported health (Short Form-12, n = 28) and circulating C-reactive protein (CRP) (n = 10). IgA-deficient individuals had lower self-reported mental health (p = 0.01) and higher CRP (p < 0.05). A strong trend was found regarding prescription of antimicrobial medicine (hazard ratio = 1.19, p = 0.05). No association was found with hospital infections (hazard ratio = 1.02, p = 0.95) or self-reported physical health (p = 0.86). IgA-deficient blood donors have impaired self-reported mental health, enhanced inflammation and possibly an increased risk of infection. Despite these findings, this study does not provide sufficient evidence to warrant specific health precautions for donors with IgA deficiency.

Original language	English
Journal	A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica
Volume	126
Issue number	3
Pages (from-to)	248-256
Number of pages	9
ISSN	0903-4641
DOIs	https://doi.org/10.1111/apm.12807
Publication status	Published - 1 Mar 2018

Keywords

Blood donors
C-reactive protein
IgA deficiency
infection
quality of life

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/apm.12807

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Hauge, S. C., Jensen, C. K., Nielsen, L. K., Pedersen, O. B., Sørensen, E., Thørner, L. W., Hjalgrim, H., Erikstrup, C., Nielsen, K. R., Kaspersen, K. A., Didriksen, M., Dziegiel, M., & Ullum, H. (2018). The association of IgA deficiency on infection rate, self-perceived health, and levels of C-reactive protein in healthy blood donors. A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica, 126(3), 248-256. https://doi.org/10.1111/apm.12807

The association of IgA deficiency on infection rate, self-perceived health, and levels of C-reactive protein in healthy blood donors. / Hauge, Sabina Chaudhary; Jensen, Charlotte Kæstel; Nielsen, Leif Kofoed et al.

In: A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica, Vol. 126, No. 3, 01.03.2018, p. 248-256.

Research output: Contribution to journal › Journal article › Research › peer-review

Hauge, SC, Jensen, CK, Nielsen, LK, Pedersen, OB, Sørensen, E, Thørner, LW, Hjalgrim, H, Erikstrup, C, Nielsen, KR, Kaspersen, KA, Didriksen, M, Dziegiel, M & Ullum, H 2018, 'The association of IgA deficiency on infection rate, self-perceived health, and levels of C-reactive protein in healthy blood donors', A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica, vol. 126, no. 3, pp. 248-256. https://doi.org/10.1111/apm.12807

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abstract = "The clinical importance of immunoglobulin A (IgA) deficiency in otherwise healthy individuals is not well described. We aimed to investigate the self-reported mental and physical health and the risk of infection in IgA-deficient blood donors compared to healthy control blood donors. Infectious events, recorded in public health registries either as prescriptions filled of any antimicrobial medicine or as hospital infections, were compared between 177 IgA-deficient blood donors and 1770 control blood donors. A subset of the IgA-deficient donors were further characterized by self-reported health (Short Form-12, n = 28) and circulating C-reactive protein (CRP) (n = 10). IgA-deficient individuals had lower self-reported mental health (p = 0.01) and higher CRP (p < 0.05). A strong trend was found regarding prescription of antimicrobial medicine (hazard ratio = 1.19, p = 0.05). No association was found with hospital infections (hazard ratio = 1.02, p = 0.95) or self-reported physical health (p = 0.86). IgA-deficient blood donors have impaired self-reported mental health, enhanced inflammation and possibly an increased risk of infection. Despite these findings, this study does not provide sufficient evidence to warrant specific health precautions for donors with IgA deficiency.",

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AU - Pedersen, Ole B.

AU - Sørensen, Erik

AU - Thørner, Lise Wegner

AU - Hjalgrim, Henrik

AU - Erikstrup, Christian

AU - Nielsen, Kaspar René

AU - Kaspersen, Kathrine Agergård

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The association of IgA deficiency on infection rate, self-perceived health, and levels of C-reactive protein in healthy blood donors

Abstract

Keywords

UN SDGs

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