The association of IgA deficiency on infection rate, self-perceived health, and levels of C-reactive protein in healthy blood donors

TY - JOUR

T1 - The association of IgA deficiency on infection rate, self-perceived health, and levels of C-reactive protein in healthy blood donors

AU - Hauge, Sabina Chaudhary

AU - Jensen, Charlotte Kæstel

AU - Nielsen, Leif Kofoed

AU - Pedersen, Ole B.

AU - Sørensen, Erik

AU - Thørner, Lise Wegner

AU - Hjalgrim, Henrik

AU - Erikstrup, Christian

AU - Nielsen, Kaspar René

AU - Kaspersen, Kathrine Agergård

AU - Didriksen, Maria

AU - Dziegiel, Morten

AU - Ullum, Henrik

PY - 2018/3/1

Y1 - 2018/3/1

N2 - The clinical importance of immunoglobulin A (IgA) deficiency in otherwise healthy individuals is not well described. We aimed to investigate the self-reported mental and physical health and the risk of infection in IgA-deficient blood donors compared to healthy control blood donors. Infectious events, recorded in public health registries either as prescriptions filled of any antimicrobial medicine or as hospital infections, were compared between 177 IgA-deficient blood donors and 1770 control blood donors. A subset of the IgA-deficient donors were further characterized by self-reported health (Short Form-12, n = 28) and circulating C-reactive protein (CRP) (n = 10). IgA-deficient individuals had lower self-reported mental health (p = 0.01) and higher CRP (p < 0.05). A strong trend was found regarding prescription of antimicrobial medicine (hazard ratio = 1.19, p = 0.05). No association was found with hospital infections (hazard ratio = 1.02, p = 0.95) or self-reported physical health (p = 0.86). IgA-deficient blood donors have impaired self-reported mental health, enhanced inflammation and possibly an increased risk of infection. Despite these findings, this study does not provide sufficient evidence to warrant specific health precautions for donors with IgA deficiency.

AB - The clinical importance of immunoglobulin A (IgA) deficiency in otherwise healthy individuals is not well described. We aimed to investigate the self-reported mental and physical health and the risk of infection in IgA-deficient blood donors compared to healthy control blood donors. Infectious events, recorded in public health registries either as prescriptions filled of any antimicrobial medicine or as hospital infections, were compared between 177 IgA-deficient blood donors and 1770 control blood donors. A subset of the IgA-deficient donors were further characterized by self-reported health (Short Form-12, n = 28) and circulating C-reactive protein (CRP) (n = 10). IgA-deficient individuals had lower self-reported mental health (p = 0.01) and higher CRP (p < 0.05). A strong trend was found regarding prescription of antimicrobial medicine (hazard ratio = 1.19, p = 0.05). No association was found with hospital infections (hazard ratio = 1.02, p = 0.95) or self-reported physical health (p = 0.86). IgA-deficient blood donors have impaired self-reported mental health, enhanced inflammation and possibly an increased risk of infection. Despite these findings, this study does not provide sufficient evidence to warrant specific health precautions for donors with IgA deficiency.

KW - Blood donors

KW - C-reactive protein

KW - IgA deficiency

KW - infection

KW - quality of life

UR - http://www.scopus.com/inward/record.url?scp=85042541689&partnerID=8YFLogxK

U2 - 10.1111/apm.12807

DO - 10.1111/apm.12807

M3 - Journal article

C2 - 29484746

AN - SCOPUS:85042541689

SN - 0903-4641

VL - 126

SP - 248

EP - 256

JO - A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica

JF - A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica

IS - 3

ER -