The association between plasma miR-122-5p release pattern at admission and all-cause mortality or shock after out-of-hospital cardiac arrest

TY - JOUR

T1 - The association between plasma miR-122-5p release pattern at admission and all-cause mortality or shock after out-of-hospital cardiac arrest

AU - Gilje, Patrik

AU - Frydland, Martin

AU - Bro-Jeppesen, John

AU - Dankiewicz, Josef

AU - Friberg, Hans

AU - Rundgren, Malin

AU - Devaux, Yvan

AU - Stammet, Pascal

AU - Al-Mashat, Mariam

AU - Jögi, Jonas

AU - Kjærgaard, Jesper

AU - Hassager, Christian

AU - Erlinge, David

PY - 2019/1/2

Y1 - 2019/1/2

N2 - BACKGROUND: Data suggests that the plasma levels of the liver-specific miR-122-5p might both be a marker of cardiogenic shock and a prognostic marker of out-of-hospital cardiac arrest (OHCA). Our aim was to characterize plasma miR-122-5p at admission after OHCA and to assess the association between miR-122-5p and relevant clinical factors such all-cause mortality and shock at admission after OHCA.METHODS: In the pilot trial, 10 survivors after OHCA were compared to 10 age- and sex-matched controls. In the main trial, 167 unconscious survivors of OHCA from the Targeted Temperature Management (TTM) trial were included.RESULTS: In the pilot trial, plasma miR-122-5p at admission after OHCA was 400-fold elevated compared to controls. In the main trial, plasma miR-122-5p at admission was independently associated with lactate and bystander cardiopulmonary resuscitation. miR-122-5p at admission was not associated with shock at admission (p = 0.14) or all-cause mortality (p = 0.35). Target temperature (33 °C vs 36 °C) was not associated with miR-122-5p levels at any time point.CONCLUSIONS: After OHCA, miR-122-5p demonstrated a marked acute increase in plasma and was independently associated with lactate and bystander resuscitation. However, miR-122-5p at admission was not associated with all-cause mortality or shock at admission.

AB - BACKGROUND: Data suggests that the plasma levels of the liver-specific miR-122-5p might both be a marker of cardiogenic shock and a prognostic marker of out-of-hospital cardiac arrest (OHCA). Our aim was to characterize plasma miR-122-5p at admission after OHCA and to assess the association between miR-122-5p and relevant clinical factors such all-cause mortality and shock at admission after OHCA.METHODS: In the pilot trial, 10 survivors after OHCA were compared to 10 age- and sex-matched controls. In the main trial, 167 unconscious survivors of OHCA from the Targeted Temperature Management (TTM) trial were included.RESULTS: In the pilot trial, plasma miR-122-5p at admission after OHCA was 400-fold elevated compared to controls. In the main trial, plasma miR-122-5p at admission was independently associated with lactate and bystander cardiopulmonary resuscitation. miR-122-5p at admission was not associated with shock at admission (p = 0.14) or all-cause mortality (p = 0.35). Target temperature (33 °C vs 36 °C) was not associated with miR-122-5p levels at any time point.CONCLUSIONS: After OHCA, miR-122-5p demonstrated a marked acute increase in plasma and was independently associated with lactate and bystander resuscitation. However, miR-122-5p at admission was not associated with all-cause mortality or shock at admission.

KW - Aged

KW - Cardiopulmonary Resuscitation

KW - Case-Control Studies

KW - Female

KW - Humans

KW - Lactic Acid/blood

KW - Male

KW - MicroRNAs/blood

KW - Middle Aged

KW - Mortality

KW - Out-of-Hospital Cardiac Arrest/blood

KW - Pilot Projects

KW - Shock/blood

KW - Survivors

U2 - 10.1080/1354750X.2018.1499804

DO - 10.1080/1354750X.2018.1499804

M3 - Journal article

C2 - 30015516

SN - 1354-750X

VL - 24

SP - 29

EP - 35

JO - Biomarkers

JF - Biomarkers

IS - 1

ER -