The association between plasma miR-122-5p release pattern at admission and all-cause mortality or shock after out-of-hospital cardiac arrest

Patrik Gilje; Martin Frydland; John Bro-Jeppesen; Josef Dankiewicz; Hans Friberg; Malin Rundgren; Yvan Devaux; Pascal Stammet; Mariam Al-Mashat; Jonas Jögi; Jesper Kjærgaard; Christian Hassager; David Erlinge

doi:10.1080/1354750X.2018.1499804

The association between plasma miR-122-5p release pattern at admission and all-cause mortality or shock after out-of-hospital cardiac arrest

Patrik Gilje, Martin Frydland, John Bro-Jeppesen, Josef Dankiewicz, Hans Friberg, Malin Rundgren, Yvan Devaux, Pascal Stammet, Mariam Al-Mashat, Jonas Jögi, Jesper Kjærgaard, Christian Hassager, David Erlinge

Institut for Klinisk Medicin

3 Citationer (Scopus)

14 Downloads (Pure)

Abstract

BACKGROUND: Data suggests that the plasma levels of the liver-specific miR-122-5p might both be a marker of cardiogenic shock and a prognostic marker of out-of-hospital cardiac arrest (OHCA). Our aim was to characterize plasma miR-122-5p at admission after OHCA and to assess the association between miR-122-5p and relevant clinical factors such all-cause mortality and shock at admission after OHCA.

METHODS: In the pilot trial, 10 survivors after OHCA were compared to 10 age- and sex-matched controls. In the main trial, 167 unconscious survivors of OHCA from the Targeted Temperature Management (TTM) trial were included.

RESULTS: In the pilot trial, plasma miR-122-5p at admission after OHCA was 400-fold elevated compared to controls. In the main trial, plasma miR-122-5p at admission was independently associated with lactate and bystander cardiopulmonary resuscitation. miR-122-5p at admission was not associated with shock at admission (p = 0.14) or all-cause mortality (p = 0.35). Target temperature (33 °C vs 36 °C) was not associated with miR-122-5p levels at any time point.

CONCLUSIONS: After OHCA, miR-122-5p demonstrated a marked acute increase in plasma and was independently associated with lactate and bystander resuscitation. However, miR-122-5p at admission was not associated with all-cause mortality or shock at admission.

Originalsprog	Engelsk
Tidsskrift	Biomarkers
Vol/bind	24
Udgave nummer	1
Sider (fra-til)	29-35
Antal sider	7
ISSN	1354-750X
DOI	https://doi.org/10.1080/1354750X.2018.1499804
Status	Udgivet - 2 jan. 2019

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10.1080/1354750X.2018.1499804

The association between plasma miR-122-5p release pattern at admission and all-cause mortality or shock after out-of-hospital cardiac arrestForlagets udgivne version, 1,4 MB

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Gilje, P., Frydland, M., Bro-Jeppesen, J., Dankiewicz, J., Friberg, H., Rundgren, M., Devaux, Y., Stammet, P., Al-Mashat, M., Jögi, J., Kjærgaard, J., Hassager, C., & Erlinge, D. (2019). The association between plasma miR-122-5p release pattern at admission and all-cause mortality or shock after out-of-hospital cardiac arrest. Biomarkers, 24(1), 29-35. https://doi.org/10.1080/1354750X.2018.1499804

Gilje, P, Frydland, M, Bro-Jeppesen, J, Dankiewicz, J, Friberg, H, Rundgren, M, Devaux, Y, Stammet, P, Al-Mashat, M, Jögi, J, Kjærgaard, J, Hassager, C & Erlinge, D 2019, 'The association between plasma miR-122-5p release pattern at admission and all-cause mortality or shock after out-of-hospital cardiac arrest', Biomarkers, bind 24, nr. 1, s. 29-35. https://doi.org/10.1080/1354750X.2018.1499804

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title = "The association between plasma miR-122-5p release pattern at admission and all-cause mortality or shock after out-of-hospital cardiac arrest",

abstract = "BACKGROUND: Data suggests that the plasma levels of the liver-specific miR-122-5p might both be a marker of cardiogenic shock and a prognostic marker of out-of-hospital cardiac arrest (OHCA). Our aim was to characterize plasma miR-122-5p at admission after OHCA and to assess the association between miR-122-5p and relevant clinical factors such all-cause mortality and shock at admission after OHCA.METHODS: In the pilot trial, 10 survivors after OHCA were compared to 10 age- and sex-matched controls. In the main trial, 167 unconscious survivors of OHCA from the Targeted Temperature Management (TTM) trial were included.RESULTS: In the pilot trial, plasma miR-122-5p at admission after OHCA was 400-fold elevated compared to controls. In the main trial, plasma miR-122-5p at admission was independently associated with lactate and bystander cardiopulmonary resuscitation. miR-122-5p at admission was not associated with shock at admission (p = 0.14) or all-cause mortality (p = 0.35). Target temperature (33 °C vs 36 °C) was not associated with miR-122-5p levels at any time point.CONCLUSIONS: After OHCA, miR-122-5p demonstrated a marked acute increase in plasma and was independently associated with lactate and bystander resuscitation. However, miR-122-5p at admission was not associated with all-cause mortality or shock at admission.",

keywords = "Aged, Cardiopulmonary Resuscitation, Case-Control Studies, Female, Humans, Lactic Acid/blood, Male, MicroRNAs/blood, Middle Aged, Mortality, Out-of-Hospital Cardiac Arrest/blood, Pilot Projects, Shock/blood, Survivors",

author = "Patrik Gilje and Martin Frydland and John Bro-Jeppesen and Josef Dankiewicz and Hans Friberg and Malin Rundgren and Yvan Devaux and Pascal Stammet and Mariam Al-Mashat and Jonas J{\"o}gi and Jesper Kj{\ae}rgaard and Christian Hassager and David Erlinge",

year = "2019",

month = jan,

day = "2",

doi = "10.1080/1354750X.2018.1499804",

language = "English",

volume = "24",

pages = "29--35",

journal = "Biomarkers",

issn = "1354-750X",

publisher = "Taylor & Francis",

number = "1",

}

TY - JOUR

T1 - The association between plasma miR-122-5p release pattern at admission and all-cause mortality or shock after out-of-hospital cardiac arrest

AU - Gilje, Patrik

AU - Frydland, Martin

AU - Bro-Jeppesen, John

AU - Dankiewicz, Josef

AU - Friberg, Hans

AU - Rundgren, Malin

AU - Devaux, Yvan

AU - Stammet, Pascal

AU - Al-Mashat, Mariam

AU - Jögi, Jonas

AU - Kjærgaard, Jesper

AU - Hassager, Christian

AU - Erlinge, David

PY - 2019/1/2

Y1 - 2019/1/2

N2 - BACKGROUND: Data suggests that the plasma levels of the liver-specific miR-122-5p might both be a marker of cardiogenic shock and a prognostic marker of out-of-hospital cardiac arrest (OHCA). Our aim was to characterize plasma miR-122-5p at admission after OHCA and to assess the association between miR-122-5p and relevant clinical factors such all-cause mortality and shock at admission after OHCA.METHODS: In the pilot trial, 10 survivors after OHCA were compared to 10 age- and sex-matched controls. In the main trial, 167 unconscious survivors of OHCA from the Targeted Temperature Management (TTM) trial were included.RESULTS: In the pilot trial, plasma miR-122-5p at admission after OHCA was 400-fold elevated compared to controls. In the main trial, plasma miR-122-5p at admission was independently associated with lactate and bystander cardiopulmonary resuscitation. miR-122-5p at admission was not associated with shock at admission (p = 0.14) or all-cause mortality (p = 0.35). Target temperature (33 °C vs 36 °C) was not associated with miR-122-5p levels at any time point.CONCLUSIONS: After OHCA, miR-122-5p demonstrated a marked acute increase in plasma and was independently associated with lactate and bystander resuscitation. However, miR-122-5p at admission was not associated with all-cause mortality or shock at admission.

AB - BACKGROUND: Data suggests that the plasma levels of the liver-specific miR-122-5p might both be a marker of cardiogenic shock and a prognostic marker of out-of-hospital cardiac arrest (OHCA). Our aim was to characterize plasma miR-122-5p at admission after OHCA and to assess the association between miR-122-5p and relevant clinical factors such all-cause mortality and shock at admission after OHCA.METHODS: In the pilot trial, 10 survivors after OHCA were compared to 10 age- and sex-matched controls. In the main trial, 167 unconscious survivors of OHCA from the Targeted Temperature Management (TTM) trial were included.RESULTS: In the pilot trial, plasma miR-122-5p at admission after OHCA was 400-fold elevated compared to controls. In the main trial, plasma miR-122-5p at admission was independently associated with lactate and bystander cardiopulmonary resuscitation. miR-122-5p at admission was not associated with shock at admission (p = 0.14) or all-cause mortality (p = 0.35). Target temperature (33 °C vs 36 °C) was not associated with miR-122-5p levels at any time point.CONCLUSIONS: After OHCA, miR-122-5p demonstrated a marked acute increase in plasma and was independently associated with lactate and bystander resuscitation. However, miR-122-5p at admission was not associated with all-cause mortality or shock at admission.

KW - Aged

KW - Cardiopulmonary Resuscitation

KW - Case-Control Studies

KW - Female

KW - Humans

KW - Lactic Acid/blood

KW - Male

KW - MicroRNAs/blood

KW - Middle Aged

KW - Mortality

KW - Out-of-Hospital Cardiac Arrest/blood

KW - Pilot Projects

KW - Shock/blood

KW - Survivors

U2 - 10.1080/1354750X.2018.1499804

DO - 10.1080/1354750X.2018.1499804

M3 - Journal article

C2 - 30015516

SN - 1354-750X

VL - 24

SP - 29

EP - 35

JO - Biomarkers

JF - Biomarkers

IS - 1

ER -

The association between plasma miR-122-5p release pattern at admission and all-cause mortality or shock after out-of-hospital cardiac arrest

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