The apoptosis linked gene ALG-2 is dysregulated in tumors of various origin and contributes to cancer cell viability

Jonas la Cour; Berit Rahbek Høj; Jens Mollerup; Ronald Simon; Guido Sauter; Martin Werner Berchtold

doi:10.1016/j.molonc.2007.08.002

The apoptosis linked gene ALG-2 is dysregulated in tumors of various origin and contributes to cancer cell viability

Jonas la Cour, Berit Rahbek Høj, Jens Mollerup, Ronald Simon, Guido Sauter, Martin Werner Berchtold

Cell Biology and Physiology

40 Citations (Scopus)

Abstract

The apoptosis linked gene-2 (ALG-2), discovered as a proapoptotic calcium binding protein, has recently been found upregulated in lung cancer tissue indicating that this protein may play a role in the pathology of cancer cells and/or may be a tumor marker. Using immunohistochemistry on tissue microarrays we analysed the expression of ALG-2 in 7371 tumor tissue samples of various origin as well as in 749 normal tissue samples. Most notably, ALG-2 was upregulated in mesenchymal tumors. No correlation was found between ALG-2 staining intensity and survival of patients with lung, breast or colon cancer. siRNA mediated ALG-2 downregulation led to a significant reduction in viability of HeLa cells indicating that ALG-2 may contribute to tumor development and expansion.

Original language	English
Journal	Molecular Oncology
Volume	1
Issue number	4
Pages (from-to)	431-439
Number of pages	9
ISSN	1574-7891
DOIs	https://doi.org/10.1016/j.molonc.2007.08.002
Publication status	Published - 2008

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10.1016/j.molonc.2007.08.002

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@article{907fdaf0dd8511ddb5fc000ea68e967b,

title = "The apoptosis linked gene ALG-2 is dysregulated in tumors of various origin and contributes to cancer cell viability",

abstract = "The apoptosis linked gene-2 (ALG-2), discovered as a proapoptotic calcium binding protein, has recently been found upregulated in lung cancer tissue indicating that this protein may play a role in the pathology of cancer cells and/or may be a tumor marker. Using immunohistochemistry on tissue microarrays we analysed the expression of ALG-2 in 7371 tumor tissue samples of various origin as well as in 749 normal tissue samples. Most notably, ALG-2 was upregulated in mesenchymal tumors. No correlation was found between ALG-2 staining intensity and survival of patients with lung, breast or colon cancer. siRNA mediated ALG-2 downregulation led to a significant reduction in viability of HeLa cells indicating that ALG-2 may contribute to tumor development and expansion.",

author = "{la Cour}, Jonas and H{\o}j, {Berit Rahbek} and Jens Mollerup and Ronald Simon and Guido Sauter and Berchtold, {Martin Werner}",

note = "Keywords: Calcium binding proteins, Tissue microarray, Gene silencing, ALG-2",

year = "2008",

doi = "10.1016/j.molonc.2007.08.002",

language = "English",

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T1 - The apoptosis linked gene ALG-2 is dysregulated in tumors of various origin and contributes to cancer cell viability

AU - la Cour, Jonas

AU - Høj, Berit Rahbek

AU - Mollerup, Jens

AU - Simon, Ronald

AU - Sauter, Guido

AU - Berchtold, Martin Werner

N1 - Keywords: Calcium binding proteins, Tissue microarray, Gene silencing, ALG-2

PY - 2008

Y1 - 2008

N2 - The apoptosis linked gene-2 (ALG-2), discovered as a proapoptotic calcium binding protein, has recently been found upregulated in lung cancer tissue indicating that this protein may play a role in the pathology of cancer cells and/or may be a tumor marker. Using immunohistochemistry on tissue microarrays we analysed the expression of ALG-2 in 7371 tumor tissue samples of various origin as well as in 749 normal tissue samples. Most notably, ALG-2 was upregulated in mesenchymal tumors. No correlation was found between ALG-2 staining intensity and survival of patients with lung, breast or colon cancer. siRNA mediated ALG-2 downregulation led to a significant reduction in viability of HeLa cells indicating that ALG-2 may contribute to tumor development and expansion.

AB - The apoptosis linked gene-2 (ALG-2), discovered as a proapoptotic calcium binding protein, has recently been found upregulated in lung cancer tissue indicating that this protein may play a role in the pathology of cancer cells and/or may be a tumor marker. Using immunohistochemistry on tissue microarrays we analysed the expression of ALG-2 in 7371 tumor tissue samples of various origin as well as in 749 normal tissue samples. Most notably, ALG-2 was upregulated in mesenchymal tumors. No correlation was found between ALG-2 staining intensity and survival of patients with lung, breast or colon cancer. siRNA mediated ALG-2 downregulation led to a significant reduction in viability of HeLa cells indicating that ALG-2 may contribute to tumor development and expansion.

U2 - 10.1016/j.molonc.2007.08.002

DO - 10.1016/j.molonc.2007.08.002

M3 - Journal article

C2 - 19383317

SN - 1574-7891

VL - 1

SP - 431

EP - 439

JO - Molecular Oncology

JF - Molecular Oncology

IS - 4

ER -

The apoptosis linked gene ALG-2 is dysregulated in tumors of various origin and contributes to cancer cell viability

Abstract

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