@article{907fdaf0dd8511ddb5fc000ea68e967b,
title = "The apoptosis linked gene ALG-2 is dysregulated in tumors of various origin and contributes to cancer cell viability",
abstract = "The apoptosis linked gene-2 (ALG-2), discovered as a proapoptotic calcium binding protein, has recently been found upregulated in lung cancer tissue indicating that this protein may play a role in the pathology of cancer cells and/or may be a tumor marker. Using immunohistochemistry on tissue microarrays we analysed the expression of ALG-2 in 7371 tumor tissue samples of various origin as well as in 749 normal tissue samples. Most notably, ALG-2 was upregulated in mesenchymal tumors. No correlation was found between ALG-2 staining intensity and survival of patients with lung, breast or colon cancer. siRNA mediated ALG-2 downregulation led to a significant reduction in viability of HeLa cells indicating that ALG-2 may contribute to tumor development and expansion.",
author = "{la Cour}, Jonas and H{\o}j, {Berit Rahbek} and Jens Mollerup and Ronald Simon and Guido Sauter and Berchtold, {Martin Werner}",
note = "Keywords: Calcium binding proteins, Tissue microarray, Gene silencing, ALG-2",
year = "2008",
doi = "10.1016/j.molonc.2007.08.002",
language = "English",
volume = "1",
pages = "431--439",
journal = "Molecular Oncology",
issn = "1574-7891",
publisher = "Elsevier",
number = "4",
}
