Abstract
Multiple sclerosis is an inflammatory disease of the CNS and a leading cause of disability. Inflammatory mediators play an orchestrating part in lesional development leading to symptoms. Chemokines -- chemoattractant cytokines -- regulate the inflammatory composite of the MS lesion. This review focuses on the present data regarding CXCL10 (previously known as IP-10) and CXRC3 in multiple sclerosis, since consistent data has suggested that this chemokine/chemokine receptor pair has a pivotal role in leukocyte recruitment into the central nervous system (CNS) in multiple sclerosis.
| Original language | English |
|---|---|
| Journal | Current Neurovascular Research |
| Volume | 1 |
| Issue number | 2 |
| Pages (from-to) | 183-90 |
| Number of pages | 8 |
| ISSN | 1567-2026 |
| Publication status | Published - Apr 2004 |
Keywords
- Animals
- Central Nervous System
- Chemokine CXCL10
- Chemokines, CXC
- Humans
- Ligands
- Multiple Sclerosis
- Receptors, CXCR3
- Receptors, Chemokine