Targeting the chemokine receptor CXCR3 and its ligand CXCL10 in the central nervous system: potential therapy for inflammatory demyelinating disease?

TY - JOUR

T1 - Targeting the chemokine receptor CXCR3 and its ligand CXCL10 in the central nervous system

T2 - potential therapy for inflammatory demyelinating disease?

AU - Sørensen, Torben Lykke

PY - 2004/4

Y1 - 2004/4

N2 - Multiple sclerosis is an inflammatory disease of the CNS and a leading cause of disability. Inflammatory mediators play an orchestrating part in lesional development leading to symptoms. Chemokines -- chemoattractant cytokines -- regulate the inflammatory composite of the MS lesion. This review focuses on the present data regarding CXCL10 (previously known as IP-10) and CXRC3 in multiple sclerosis, since consistent data has suggested that this chemokine/chemokine receptor pair has a pivotal role in leukocyte recruitment into the central nervous system (CNS) in multiple sclerosis.

AB - Multiple sclerosis is an inflammatory disease of the CNS and a leading cause of disability. Inflammatory mediators play an orchestrating part in lesional development leading to symptoms. Chemokines -- chemoattractant cytokines -- regulate the inflammatory composite of the MS lesion. This review focuses on the present data regarding CXCL10 (previously known as IP-10) and CXRC3 in multiple sclerosis, since consistent data has suggested that this chemokine/chemokine receptor pair has a pivotal role in leukocyte recruitment into the central nervous system (CNS) in multiple sclerosis.

KW - Animals

KW - Central Nervous System

KW - Chemokine CXCL10

KW - Chemokines, CXC

KW - Humans

KW - Ligands

KW - Multiple Sclerosis

KW - Receptors, CXCR3

KW - Receptors, Chemokine

M3 - Journal article

C2 - 16185193

SN - 1875-5739

VL - 1

SP - 183

EP - 190

JO - Current Neurovascular Research

JF - Current Neurovascular Research

IS - 2

ER -