Targeting Sirtuins: Substrate Specificity and Inhibitor Design

Keyphrases

• Substrate Specificity 100%
• Sirtuins 100%
• Post-translational Modification 80%
• Histone Deacetylases 40%
• Mechanism-based 20%
• Disease Treatment 20%
• Deacylase 20%
• NAD+-dependent 20%
• Proteome 20%
• Deacetylases 20%
• Gene Expression 20%
• Lysine 20%
• Cell Behavior 20%
• Metabolism 20%
• Lysine Residue 20%
• Sirtuin Inhibitors 20%
• Acetyl-lysine 20%
• Functional Diversity 20%
• Epigenetic Effects 20%
• Neurodegenerative Diseases 20%
• Hydrolases 20%
• Therapeutic Target 20%
• Structural Diversity 20%

Biochemistry, Genetics and Molecular Biology

• Enzyme Specificity 100%
• Sirtuin 100%
• Posttranslational Modification 66%
• Enzyme 50%
• Lysine 33%
• Histone Deacetylase 33%
• Proteome 16%
• Epigenetics 16%
• Cell Function 16%
• Hydrolase 16%
• Metabolic Pathway 16%
• Gene Expression 16%
• Cell Membrane Potential 16%