T-cell response in human leishmaniasis

A Kharazmi; K Kemp; A Ismail; S Gasim; A Gaafar; J A Kurtzhals; A M El Hassan; T G Theander; M Kemp

T-cell response in human leishmaniasis

A Kharazmi, K Kemp, A Ismail, S Gasim, A Gaafar, J A Kurtzhals, A M El Hassan, T G Theander, M Kemp

77 Citations (Scopus)

Abstract

In the present communication we provide evidence for the existence of a Th1/Th2 dichotomy in the T-cell response to Leishmania antigens in human leishmaniasis. Our data suggest that the pattern of IL-4 and IFN-gamma response is polarised in these patients. Lymphocytes from individuals recovered from cutaneous leishmaniasis (CL) responded by IFN-gamma production following stimulation with Leishmania antigens whereas cells from patients recovered from visceral leishmaniasis (VL) showed a mixed pattern of IFN-gamma and IL-4 responses. The cells producing these cytokines were predominantly CD4+. Furthermore, IL-10 plays an important role in the development of post kala azar dermal leishmaniasis (PKDL) from VL. The balance between the parasitic-specific T-cell response plays an important regulatory role in determining the outcome of Leishmania infections in humans.

Original language	English
Journal	Immunology Letters
Volume	65
Issue number	1-2
Pages (from-to)	105-8
Number of pages	3
ISSN	0165-2478
Publication status	Published - 1999

Cite this

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title = "T-cell response in human leishmaniasis",

abstract = "In the present communication we provide evidence for the existence of a Th1/Th2 dichotomy in the T-cell response to Leishmania antigens in human leishmaniasis. Our data suggest that the pattern of IL-4 and IFN-gamma response is polarised in these patients. Lymphocytes from individuals recovered from cutaneous leishmaniasis (CL) responded by IFN-gamma production following stimulation with Leishmania antigens whereas cells from patients recovered from visceral leishmaniasis (VL) showed a mixed pattern of IFN-gamma and IL-4 responses. The cells producing these cytokines were predominantly CD4+. Furthermore, IL-10 plays an important role in the development of post kala azar dermal leishmaniasis (PKDL) from VL. The balance between the parasitic-specific T-cell response plays an important regulatory role in determining the outcome of Leishmania infections in humans.",

author = "A Kharazmi and K Kemp and A Ismail and S Gasim and A Gaafar and Kurtzhals, {J A} and {El Hassan}, {A M} and Theander, {T G} and M Kemp",

note = "Keywords: Antigens, Protozoan; Cytokines; Humans; Leishmaniasis, Cutaneous; Leishmaniasis, Visceral; T-Lymphocytes",

year = "1999",

language = "English",

volume = "65",

pages = "105--8",

journal = "Immunology Letters",

issn = "0165-2478",

publisher = "Elsevier",

number = "1-2",

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TY - JOUR

T1 - T-cell response in human leishmaniasis

AU - Kharazmi, A

AU - Kemp, K

AU - Ismail, A

AU - Gasim, S

AU - Gaafar, A

AU - Kurtzhals, J A

AU - El Hassan, A M

AU - Theander, T G

AU - Kemp, M

N1 - Keywords: Antigens, Protozoan; Cytokines; Humans; Leishmaniasis, Cutaneous; Leishmaniasis, Visceral; T-Lymphocytes

PY - 1999

Y1 - 1999

N2 - In the present communication we provide evidence for the existence of a Th1/Th2 dichotomy in the T-cell response to Leishmania antigens in human leishmaniasis. Our data suggest that the pattern of IL-4 and IFN-gamma response is polarised in these patients. Lymphocytes from individuals recovered from cutaneous leishmaniasis (CL) responded by IFN-gamma production following stimulation with Leishmania antigens whereas cells from patients recovered from visceral leishmaniasis (VL) showed a mixed pattern of IFN-gamma and IL-4 responses. The cells producing these cytokines were predominantly CD4+. Furthermore, IL-10 plays an important role in the development of post kala azar dermal leishmaniasis (PKDL) from VL. The balance between the parasitic-specific T-cell response plays an important regulatory role in determining the outcome of Leishmania infections in humans.

AB - In the present communication we provide evidence for the existence of a Th1/Th2 dichotomy in the T-cell response to Leishmania antigens in human leishmaniasis. Our data suggest that the pattern of IL-4 and IFN-gamma response is polarised in these patients. Lymphocytes from individuals recovered from cutaneous leishmaniasis (CL) responded by IFN-gamma production following stimulation with Leishmania antigens whereas cells from patients recovered from visceral leishmaniasis (VL) showed a mixed pattern of IFN-gamma and IL-4 responses. The cells producing these cytokines were predominantly CD4+. Furthermore, IL-10 plays an important role in the development of post kala azar dermal leishmaniasis (PKDL) from VL. The balance between the parasitic-specific T-cell response plays an important regulatory role in determining the outcome of Leishmania infections in humans.

M3 - Journal article

C2 - 10065635

SN - 0165-2478

VL - 65

SP - 105

EP - 108

JO - Immunology Letters

JF - Immunology Letters

IS - 1-2

ER -

T-cell response in human leishmaniasis

Abstract

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