@article{2da1c720a0d811dd86a6000ea68e967b,
title = "T-cell response in human leishmaniasis",
abstract = "In the present communication we provide evidence for the existence of a Th1/Th2 dichotomy in the T-cell response to Leishmania antigens in human leishmaniasis. Our data suggest that the pattern of IL-4 and IFN-gamma response is polarised in these patients. Lymphocytes from individuals recovered from cutaneous leishmaniasis (CL) responded by IFN-gamma production following stimulation with Leishmania antigens whereas cells from patients recovered from visceral leishmaniasis (VL) showed a mixed pattern of IFN-gamma and IL-4 responses. The cells producing these cytokines were predominantly CD4+. Furthermore, IL-10 plays an important role in the development of post kala azar dermal leishmaniasis (PKDL) from VL. The balance between the parasitic-specific T-cell response plays an important regulatory role in determining the outcome of Leishmania infections in humans.",
author = "A Kharazmi and K Kemp and A Ismail and S Gasim and A Gaafar and Kurtzhals, {J A} and {El Hassan}, {A M} and Theander, {T G} and M Kemp",
note = "Keywords: Antigens, Protozoan; Cytokines; Humans; Leishmaniasis, Cutaneous; Leishmaniasis, Visceral; T-Lymphocytes",
year = "1999",
language = "English",
volume = "65",
pages = "105--8",
journal = "Immunology Letters",
issn = "0165-2478",
publisher = "Elsevier",
number = "1-2",
}