Systematic reviews of diagnostic test accuracy

Mariska M G Leeflang; Jonathan J Deeks; Constantine Gatsonis; Patrick M M Bossuyt; Jørgen Hilden

Systematic reviews of diagnostic test accuracy

Mariska M G Leeflang, Jonathan J Deeks, Constantine Gatsonis, Patrick M M Bossuyt, Jørgen Hilden

Section of Biostatistics

776 Citations (Scopus)

Abstract

More and more systematic reviews of diagnostic test accuracy studies are being published, but they can be methodologically challenging. In this paper, the authors present some of the recent developments in the methodology for conducting systematic reviews of diagnostic test accuracy studies. Restrictive electronic search filters are discouraged, as is the use of summary quality scores. Methods for meta-analysis should take into account the paired nature of the estimates and their dependence on threshold. Authors of these reviews are advised to use the hierarchical summary receiver-operating characteristic or the bivariate model for the data analysis. Challenges that remain are the poor reporting of original diagnostic test accuracy studies and difficulties with the interpretation of the results of diagnostic test accuracy research.

Original language	English
Journal	Annals of Internal Medicine
Volume	149
Issue number	12
Pages (from-to)	889-97
Number of pages	8
ISSN	0003-4819
Publication status	Published - 2008

Cite this

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AU - Deeks, Jonathan J

AU - Gatsonis, Constantine

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AU - Hilden, Jørgen

N1 - Keywords: Diagnostic Tests, Routine; Humans; Information Storage and Retrieval; Meta-Analysis as Topic; ROC Curve; Research Design; Review Literature as Topic; Sensitivity and Specificity

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N2 - More and more systematic reviews of diagnostic test accuracy studies are being published, but they can be methodologically challenging. In this paper, the authors present some of the recent developments in the methodology for conducting systematic reviews of diagnostic test accuracy studies. Restrictive electronic search filters are discouraged, as is the use of summary quality scores. Methods for meta-analysis should take into account the paired nature of the estimates and their dependence on threshold. Authors of these reviews are advised to use the hierarchical summary receiver-operating characteristic or the bivariate model for the data analysis. Challenges that remain are the poor reporting of original diagnostic test accuracy studies and difficulties with the interpretation of the results of diagnostic test accuracy research.

AB - More and more systematic reviews of diagnostic test accuracy studies are being published, but they can be methodologically challenging. In this paper, the authors present some of the recent developments in the methodology for conducting systematic reviews of diagnostic test accuracy studies. Restrictive electronic search filters are discouraged, as is the use of summary quality scores. Methods for meta-analysis should take into account the paired nature of the estimates and their dependence on threshold. Authors of these reviews are advised to use the hierarchical summary receiver-operating characteristic or the bivariate model for the data analysis. Challenges that remain are the poor reporting of original diagnostic test accuracy studies and difficulties with the interpretation of the results of diagnostic test accuracy research.

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VL - 149

SP - 889

EP - 897

JO - Annals of Internal Medicine

JF - Annals of Internal Medicine

IS - 12

ER -

Systematic reviews of diagnostic test accuracy

Abstract

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