Synthetic NCAM-derived Ligands of the Fibroblast Growth Factor Receptor

Stine Hansen; Shizhong Li; Elisabeth Bock; Vladimir Berezin

doi:10.1007/s11064-008-9707-8

Synthetic NCAM-derived Ligands of the Fibroblast Growth Factor Receptor

Stine Hansen, Shizhong Li, Elisabeth Bock, Vladimir Berezin

Abstract

The neural cell adhesion molecule (NCAM) responds to cues in the external environment and transmits signals to the cell through extracellular and intracellular interactions with a number of other signal transduction molecules. One such NCAM interaction partner is the fibroblast growth factor receptor (FGFR). NCAM interacts with FGFR via two fibronectin type III (FN3) modules in the extracellular part of NCAM. These modules consist of beta-strands and connecting loop regions. Based on structural analysis of the NCAM FN3 modules, four peptide sequences, FGL, BCL, dekaCAM, and FRM, encompassing various FN3 module loop regions, have been identified as FGFR ligands. All four peptides activate FGFR and differentially modulate a number of neuronal functions, such as differentiation, survival, and synaptic changes that are important for learning, memory, and neuronal regeneration.

Original language	English
Journal	Neurochemical Research
ISSN	0364-3190
DOIs	https://doi.org/10.1007/s11064-008-9707-8
Publication status	Published - 2008

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@article{43674510fc1f11ddb219000ea68e967b,

title = "Synthetic NCAM-derived Ligands of the Fibroblast Growth Factor Receptor",

abstract = "The neural cell adhesion molecule (NCAM) responds to cues in the external environment and transmits signals to the cell through extracellular and intracellular interactions with a number of other signal transduction molecules. One such NCAM interaction partner is the fibroblast growth factor receptor (FGFR). NCAM interacts with FGFR via two fibronectin type III (FN3) modules in the extracellular part of NCAM. These modules consist of beta-strands and connecting loop regions. Based on structural analysis of the NCAM FN3 modules, four peptide sequences, FGL, BCL, dekaCAM, and FRM, encompassing various FN3 module loop regions, have been identified as FGFR ligands. All four peptides activate FGFR and differentially modulate a number of neuronal functions, such as differentiation, survival, and synaptic changes that are important for learning, memory, and neuronal regeneration.",

author = "Stine Hansen and Shizhong Li and Elisabeth Bock and Vladimir Berezin",

year = "2008",

doi = "10.1007/s11064-008-9707-8",

language = "English",

journal = "Neurochemical Research",

issn = "0364-3190",

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T1 - Synthetic NCAM-derived Ligands of the Fibroblast Growth Factor Receptor

AU - Hansen, Stine

AU - Li, Shizhong

AU - Bock, Elisabeth

AU - Berezin, Vladimir

PY - 2008

Y1 - 2008

N2 - The neural cell adhesion molecule (NCAM) responds to cues in the external environment and transmits signals to the cell through extracellular and intracellular interactions with a number of other signal transduction molecules. One such NCAM interaction partner is the fibroblast growth factor receptor (FGFR). NCAM interacts with FGFR via two fibronectin type III (FN3) modules in the extracellular part of NCAM. These modules consist of beta-strands and connecting loop regions. Based on structural analysis of the NCAM FN3 modules, four peptide sequences, FGL, BCL, dekaCAM, and FRM, encompassing various FN3 module loop regions, have been identified as FGFR ligands. All four peptides activate FGFR and differentially modulate a number of neuronal functions, such as differentiation, survival, and synaptic changes that are important for learning, memory, and neuronal regeneration.

AB - The neural cell adhesion molecule (NCAM) responds to cues in the external environment and transmits signals to the cell through extracellular and intracellular interactions with a number of other signal transduction molecules. One such NCAM interaction partner is the fibroblast growth factor receptor (FGFR). NCAM interacts with FGFR via two fibronectin type III (FN3) modules in the extracellular part of NCAM. These modules consist of beta-strands and connecting loop regions. Based on structural analysis of the NCAM FN3 modules, four peptide sequences, FGL, BCL, dekaCAM, and FRM, encompassing various FN3 module loop regions, have been identified as FGFR ligands. All four peptides activate FGFR and differentially modulate a number of neuronal functions, such as differentiation, survival, and synaptic changes that are important for learning, memory, and neuronal regeneration.

U2 - 10.1007/s11064-008-9707-8

DO - 10.1007/s11064-008-9707-8

M3 - Journal article

C2 - 18427984

SN - 0364-3190

JO - Neurochemical Research

JF - Neurochemical Research

ER -

Synthetic NCAM-derived Ligands of the Fibroblast Growth Factor Receptor

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