TY - JOUR
T1 - Synthetic NCAM-derived Ligands of the Fibroblast Growth Factor Receptor
AU - Hansen, Stine
AU - Li, Shizhong
AU - Bock, Elisabeth
AU - Berezin, Vladimir
PY - 2008
Y1 - 2008
N2 - The neural cell adhesion molecule (NCAM) responds to cues in the external environment and transmits signals to the cell through extracellular and intracellular interactions with a number of other signal transduction molecules. One such NCAM interaction partner is the fibroblast growth factor receptor (FGFR). NCAM interacts with FGFR via two fibronectin type III (FN3) modules in the extracellular part of NCAM. These modules consist of beta-strands and connecting loop regions. Based on structural analysis of the NCAM FN3 modules, four peptide sequences, FGL, BCL, dekaCAM, and FRM, encompassing various FN3 module loop regions, have been identified as FGFR ligands. All four peptides activate FGFR and differentially modulate a number of neuronal functions, such as differentiation, survival, and synaptic changes that are important for learning, memory, and neuronal regeneration.
AB - The neural cell adhesion molecule (NCAM) responds to cues in the external environment and transmits signals to the cell through extracellular and intracellular interactions with a number of other signal transduction molecules. One such NCAM interaction partner is the fibroblast growth factor receptor (FGFR). NCAM interacts with FGFR via two fibronectin type III (FN3) modules in the extracellular part of NCAM. These modules consist of beta-strands and connecting loop regions. Based on structural analysis of the NCAM FN3 modules, four peptide sequences, FGL, BCL, dekaCAM, and FRM, encompassing various FN3 module loop regions, have been identified as FGFR ligands. All four peptides activate FGFR and differentially modulate a number of neuronal functions, such as differentiation, survival, and synaptic changes that are important for learning, memory, and neuronal regeneration.
U2 - 10.1007/s11064-008-9707-8
DO - 10.1007/s11064-008-9707-8
M3 - Journal article
C2 - 18427984
SN - 0364-3190
JO - Neurochemical Research
JF - Neurochemical Research
ER -