Synthesis of peptides using tert-butyloxycarbonyl (Boc) as the α-amino protection group

Søren W Pedersen, Christopher J Armishaw, Kristian Strømgaard

    4 Citations (Scopus)

    Abstract

    The use of the tert-butyloxycarbonyl (Boc) as the Nα-amino protecting group in peptide synthesis can be advantageous in several cases, such as synthesis of hydrophobic peptides and peptides containing ester and thioester moieties. The primary challenge of using Boc SPPS is the need for treatment of the resin-bound peptide with hazardous hydrogen fluoride (HF), which requires special equipment.
    Original languageEnglish
    Title of host publicationPeptide synthesis and applications
    Number of pages16
    Volume1047
    PublisherHumana Press
    Publication date2013
    Pages65-80
    ISBN (Electronic)978-1-62703-544-6
    DOIs
    Publication statusPublished - 2013
    SeriesMethods in Molecular Biology
    ISSN1064-3745

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